Antitumor agent-92

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Antitumor agent-92, an Icaritin (HY-N0678) derivative, causes arrest at the G0/G1 phase in the cell cycle and induces cell apoptosis. Antitumor agent-92 has the potential for hepatocellular carcinoma (HCC) research.

For research use only. We do not sell to patients.

Antitumor agent-92 Chemical Structure

CAS No. : 2922842-01-9

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Description

In Vitro

Antitumor agent-92 (compound 11c; 2-8 μM; 48 h) induces apoptosis in HepG2 and SMMC-7721 cells, especially at high concentrations^[1].
Antitumor agent-92 (2-8 μM; 48 h) can induce the G0/G1 cycle arrest in HepG2 and SMMC-7721 cells^[1].
Antitumor agent-92 (2-8 μM; 48 h) upregulates P21 and downregulates Cdc2 p34 and CDK4^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	HepG2 and SMMC-7721 cells
Concentration:	2, 4, 8 μM
Incubation Time:	48 h
Result:	Apoptotic cells were observed, as evidenced by the increasing number of detached cells and fewer HepG2 and SMMC-7721 cells.

Cell Cycle Analysis^[1]

Cell Line:	HepG2 and SMMC-7721 cells
Concentration:	2, 4, 8 μM
Incubation Time:	48 h
Result:	Led to an increased percentage of cells at the G0/G1 phase from 64.22% and 58.43% of the untreated control to 83.28% and 78.95%, respectively.

Western Blot Analysis^[1]

Cell Line:	HepG2 and SMMC-7721 cells
Concentration:	2, 4, 8 μM
Incubation Time:	48 h
Result:	The level of P21 was upregulated, and Cdc2 p34 and CDK4 were downregulated.

Molecular Weight

611.68

Formula

C₃₃H₄₁NO₁₀

CAS No.

2922842-01-9

SMILES

COC1=CC=C(C=C1)C2=C(C(C3=C(C=C(C(C/C=C(C)\C)=C3O2)OCCN4CCCC4)O)=O)O[C@H]5O[C@@H]([C@H]([C@@H]([C@@H]5O)O)O)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jichong Li, et al. Synthesis and Structure-Activity Analysis of Icaritin Derivatives as Potential Tumor Growth Inhibitors of Hepatocellular Carcinoma Cells. J Nat Prod. 2023 Feb 24;86(2):290-306. [Content Brief]