2. Anti-infection
  3. Enterovirus
  4. Antiviral agent 23

Antiviral agent 23 (compound 11b) is an antiviral agent to enterovirus 71 (EV71) with an EC50 value of 94 nM. Antiviral agent 23 effectively suppresses the activity of METTL3/METTL14. Antiviral agent 23 can be used for the research of infection.

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Antiviral agent 23 Chemical Structure

Antiviral agent 23 Chemical Structure

CAS No. : 35940-03-5

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Antiviral agent 23 Related Antibodies

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Description

Antiviral agent 23 (compound 11b) is an antiviral agent to enterovirus 71 (EV71) with an EC50 value of 94 nM. Antiviral agent 23 effectively suppresses the activity of METTL3/METTL14. Antiviral agent 23 can be used for the research of infection[1].

Cellular Effect
Cell Line Type Value Description References
B16 IC50
> 166.7 μM
Compound: 12
Antitumor activity against mouse B16 cells after 72 hrs by Calcein AM assay
Antitumor activity against mouse B16 cells after 72 hrs by Calcein AM assay
[PMID: 17418578]
CCRF-CEM IC50
19.1 μM
Compound: 12
Antitumor activity against human CEM cells after 72 hrs by Calcein AM assay
Antitumor activity against human CEM cells after 72 hrs by Calcein AM assay
[PMID: 17418578]
G-361 IC50
> 166.7 μM
Compound: 12
Antitumor activity against human G361 cells after 72 hrs by Calcein AM assay
Antitumor activity against human G361 cells after 72 hrs by Calcein AM assay
[PMID: 17418578]
HL-60 IC50
6.4 μM
Compound: 12
Antitumor activity against human HL60 cells after 72 hrs by Calcein AM assay
Antitumor activity against human HL60 cells after 72 hrs by Calcein AM assay
[PMID: 17418578]
HOS IC50
> 166.7 μM
Compound: 12
Antitumor activity against human HOS cells after 72 hrs by Calcein AM assay
Antitumor activity against human HOS cells after 72 hrs by Calcein AM assay
[PMID: 17418578]
K562 IC50
> 166.7 μM
Compound: 12
Antitumor activity against human K562 cells after 72 hrs by Calcein AM assay
Antitumor activity against human K562 cells after 72 hrs by Calcein AM assay
[PMID: 17418578]
NIH3T3 IC50
> 166.7 μM
Compound: 12
Cytotoxicity against mouse NIH 3T3 cells after 72 hrs by Calcein AM assay
Cytotoxicity against mouse NIH 3T3 cells after 72 hrs by Calcein AM assay
[PMID: 17418578]
In Vitro

Antiviral agent 23 (0-100 μM) inhibits CVA21 and EV68 replication in HeLa cells with EC50 values of 36.4 and 8.9 μM, respectively[1].
Antiviral agent 23 (100 μM) inhibits the enzymatic activity of METTL3/METTL14 of 74.45%[1].
Antiviral agent 23 (0-100 μM) shows antiviral effect to EV71 and inhibits the replication of the EV71 strain BrCr in RD cells with an EC50 value of 94 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antiviral agent 23 Related Antibodies
Molecular Weight

371.39

Formula

C18H21N5O4
CAS No.
SMILES

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=CN=C3NCC4=CC=CC(C)=C4)=C3N=C2)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antiviral agent 23 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiviral agent 2335940-03-5Antiviral agent23Antiviral agent-23EnterovirusRhinovirusHRVHRVsHEVHEVsnucleoside analogueinfectionEV71CVA21EV68HeLaInhibitorinhibitorinhibit

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