2. Anti-infection
  3. Influenza Virus
  4. Antiviral agent 34

Antiviral agent 34 is a potent and orally active antiviral agent against influenza A and B subtypes with an EC50 value of 0.8 nM for H1N1 proliferation. Antiviral agent 34 derivatives inhibited influenza virus proliferation by targeting influenza virus RNA-dependent RNA polymerase. Antiviral agent 34 can be used for influenza virus research.

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Antiviral agent 34 Chemical Structure

Antiviral agent 34 Chemical Structure

CAS No. : 945152-88-5

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Antiviral agent 34 Related Antibodies

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Description

Antiviral agent 34 is a potent and orally active antiviral agent against influenza A and B subtypes with an EC50 value of 0.8 nM for H1N1 proliferation. Antiviral agent 34 derivatives inhibited influenza virus proliferation by targeting influenza virus RNA-dependent RNA polymerase. Antiviral agent 34 can be used for influenza virus research[1].

In Vitro

Antiviral agent 34 (Compound 10m) (0-470 nM, 24 h) demonstrates a high safety profile and inhibits the H1N1 virus proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antiviral agent 34 Related Antibodies

Cell Viability Assay[1]

Cell Line: MDCK cells
Concentration: 0-470 nM
Incubation Time: 24 h
Result: Exhibited low toxicity to MDCK cells.

Western Blot Analysis[1]

Cell Line: MDCK cells
Concentration: 2-125 nM
Incubation Time: 24 h
Result: Reduced the protein level of H1N1 nucleocapsid protein (NP) with low nanomolar values.

Real Time qPCR[1]

Cell Line: MDCK cells
Concentration: 2-31.3 nM
Incubation Time: 24 h
Result: Reduced the mRNA level of H1N1 nucleocapsid protein (NP) with low nanomolar values.
In Vivo

Antiviral agent 34 (Compound 10m) (1 g/kg for orally administration, three times a day and continues for 14 days) exhibits antiviral activity in a lethal influenza virus mouse model[1].

Pharmacokinetic Analysis in SD rats [1]

Route Dose (mg/kg) AUClast (ng•h/mL) AUCINF_obs (ng•h/mL) t1/2 (h) Tmax (h) Cmax (ng/mL) Clobs (L•h/kg) Vss_obs (mL/kg) MRTINF_obs (h) F (%)
i.v. 3 21944 21920 3.69 0.08 41942 2.29 / / /
p.o. 10 5416 5395 3.26 4.0d 1184 / / / 7.38

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice [1]
Dosage: 1 g/kg/d continues for 14 days
Administration: Oral gavage (p.o.)
Result: Tolerated at a dose of 1 g/kg with low acute toxicity.
Provided ~ 50% protection in mice infected with lethal-dose H1N1.
Animal Model: SD rats (Pharmacokinetic assay)[1]
Dosage: 3 mg/kg, 10 mg/kg
Administration: intravenous injection (i.v.), oral administration (p.o.)
Result: Had preferable AUC value and low clearance rate and displayed superior oral bioavailability (F = 7.38%).
Molecular Weight

487.66

Formula

C29H33N3O2S
CAS No.
SMILES

CC(C)(C)C1=CC=C(C(NC(NC2=CC=C(NC(C3=CC=C(C(C)(C)C)C=C3)=O)C=C2)=S)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antiviral agent 34 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiviral agent 34945152-88-5Antiviral agent34Antiviral agent-34Influenza Virusinfluenza virusRNA-dependent RNA polymerasenon-nucleoside polymerase inhibitorsdruggability evaluationInhibitorinhibitorinhibit

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