2. Anti-infection
  3. Virus Protease Influenza Virus SARS-CoV
  4. Antiviral agent 54

Antiviral agent 54 (compound 33) is a broad-spectrum and orally active antiviral agent. Antiviral agent 54 shows antiviral activity for ZIKV, HCoV-OC43 and influenza A virus (IVA). Antiviral agent 54 decreases the ZIKV RNA and protein level.

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Antiviral agent 54 Chemical Structure

Antiviral agent 54 Chemical Structure

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Antiviral agent 54 Related Antibodies

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Description

Antiviral agent 54 (compound 33) is a broad-spectrum and orally active antiviral agent. Antiviral agent 54 shows antiviral activity for ZIKV, HCoV-OC43 and influenza A virus (IVA). Antiviral agent 54 decreases the ZIKV RNA and protein level[1].

IC50 & Target

EC50: 0.39 µM (ZIKV); 2.28 µM (HCoV-OC43); 2.69 µM (influenza A)[1]
In Vitro

Antiviral agent 54 (compound 33) (5, 2.5, 1.25, 0.625 µM; 48 h) decreases the ZIKV NS5 protein and RNA level in a dose-dependent manner[1].
Antiviral agent 54 shows antiviral activity for ZIKV, HCoV-OC43 and influenza A virus (IVA) with EC50s of 0.39, 2.28, 2.69 µM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antiviral agent 54 Related Antibodies

Western Blot Analysis[1]

Cell Line: HUVEC cells
Concentration: 5, 2.5, 1.25, 0.625 µM
Incubation Time: 48 h
Result: Decreased the ZIKV NS5 protein level in a dose-dependent manner.

RT-PCR[1]

Cell Line: HUVEC cells
Concentration: 10 µM
Incubation Time: 48 h
Result: Decreased the ZIKV RNA level in a dose-dependent manner.
Molecular Weight

411.59

Formula

C23H37N7
SMILES

CN(C)CCN(C)CCN(C)C1=CC=NC(CN2CCN(C3=CC=NC=C3)CC2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antiviral agent 54 Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiviral agent 54Antiviral agent54Antiviral agent-54Virus ProteaseInfluenza VirusSARS-CoVSARS coronavirusHUVEC cellsZIKV RNAantiviralorally activeHCoV-OC43 and influenza A virus (IVA)Inhibitorinhibitorinhibit

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Antiviral agent 54
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HY-161454
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