2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. AP14145

AP14145 is an inhibitor for small conductance calcium-activated potassium channel, inhibits KCa2.2 channel and KCa channel with IC50 of 1.1 μM and 1.1 μM. AP14145 prolongs atrial effective refractory period (AERP) in rats, causes the conversion of atrial fibrillation to sinus rhythum in porcine left ventricular dysfunction models, and exhibits antiarrhythmic effect.

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AP14145 Chemical Structure

AP14145 Chemical Structure

CAS No. : 1446770-54-2

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Description

AP14145 is an inhibitor for small conductance calcium-activated potassium channel, inhibits KCa2.2 channel and KCa channel with IC50 of 1.1 μM and 1.1 μM. AP14145 prolongs atrial effective refractory period (AERP) in rats, causes the conversion of atrial fibrillation to sinus rhythum in porcine left ventricular dysfunction models, and exhibits antiarrhythmic effect[1][2].

Molecular Weight

362.35

Formula

C18H17F3N4O
CAS No.
SMILES

CC(NC1=C2C(N=C(N[C@@H](C3=CC=CC(C(F)(F)F)=C3)C)N2)=CC=C1)=O
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Purity & Documentation
References
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AP14145 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AP141451446770-54-2AP 14145AP-14145Potassium ChannelKcsAPorcinepigleft ventricular dysfunctionLVDsinus rhythmatrial fibrillationInhibitorinhibitorinhibit

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