2. Protein Tyrosine Kinase/RTK
  3. c-Kit
  4. AP23848

AP23848 is an ATP-dependent kinase inhibitor that effectively and selectively targets the Kit activation loop mutation both in vitro and in vivo, showing anti-tumor activity. AP23848 can inhibit the phosphorylation of the activated Kit mutation and tumor growth in mice, making it suitable for targeting diseases with the D816V mutation, such as systemic mastocytosis (SM) and acute myeloid leukemia (AML) research.

For research use only. We do not sell to patients.

AP23848 Chemical Structure

AP23848 Chemical Structure

CAS No. : 834894-21-2

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Description

AP23848 is an ATP-dependent kinase inhibitor that effectively and selectively targets the Kit activation loop mutation both in vitro and in vivo, showing anti-tumor activity. AP23848 can inhibit the phosphorylation of the activated Kit mutation and tumor growth in mice, making it suitable for targeting diseases with the D816V mutation, such as systemic mastocytosis (SM) and acute myeloid leukemia (AML) research[1].

Molecular Weight

531.63

Formula

C30H38N5O2P
CAS No.
SMILES

OC1=CC=CC(CCN2C3=NC(C4CCCC4)=NC(NC5=CC=C(P(CCC)(CCC)=O)C=C5)=C3N=C2)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AP23848 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AP23848834894-21-2AP 23848AP-23848c-KitSCFRCD117D816Vc-kitSMAMLInhibitorinhibitorinhibit

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