2. GPCR/G Protein
  3. Apelin Receptor (APJ)
  4. APJ receptor agonist 5

APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease.

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APJ receptor agonist 5 Chemical Structure

APJ receptor agonist 5 Chemical Structure

CAS No. : 2135514-20-2

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APJ receptor agonist 5 Related Antibodies

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Description

APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease[1].

Molecular Weight

479.52

Formula

C26H29N3O6
CAS No.
SMILES

CCOCC(N(C1=C(C=CC=C1OC)OC)C(O)=C2C(N3C[C@](C4=CC=CC=C4)([H])CC3)=O)=NC2=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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APJ receptor agonist 5 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

APJ receptor agonist 52135514-20-2APJ receptor agonist5APJ receptor agonist-5Apelin Receptor (APJ)oralapelin receptorheart failuretoxicologycardiac functionInhibitorinhibitorinhibit

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