2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. APN-PEG36-tetrazine

APN-PEG36-tetrazine is an analogue of APN-PEG4-tetrazine. APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). APN-PEG36-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

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APN-PEG36-tetrazine Chemical Structure

APN-PEG36-tetrazine Chemical Structure

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Based on 1 publication(s) in Google Scholar

APN-PEG36-tetrazine Related Antibodies

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Description

APN-PEG36-tetrazine is an analogue of APN-PEG4-tetrazine. APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. APN-PEG36-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

APN-PEG36-tetrazine Related Antibodies
Molecular Weight

1997.30

Formula

C94H161N7O38
Appearance

Solid

Color

Pink to red

SMILES

N#CC#CC1=CC=C(C(NCCOCCOCCC(NCC2=CC=C(C3=NN=CN=N3)C=C2)=O)=O)C=C1.[35]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (50.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5007 mL 2.5034 mL 5.0068 mL
5 mM 0.1001 mL 0.5007 mL 1.0014 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5007 mL 2.5034 mL 5.0068 mL 12.5169 mL
5 mM 0.1001 mL 0.5007 mL 1.0014 mL 2.5034 mL
10 mM 0.0501 mL 0.2503 mL 0.5007 mL 1.2517 mL
15 mM 0.0334 mL 0.1669 mL 0.3338 mL 0.8345 mL
20 mM 0.0250 mL 0.1252 mL 0.2503 mL 0.6258 mL
25 mM 0.0200 mL 0.1001 mL 0.2003 mL 0.5007 mL
30 mM 0.0167 mL 0.0834 mL 0.1669 mL 0.4172 mL
40 mM 0.0125 mL 0.0626 mL 0.1252 mL 0.3129 mL
50 mM 0.0100 mL 0.0501 mL 0.1001 mL 0.2503 mL
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APN-PEG36-tetrazine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

APN-PEG36-tetrazineADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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