Apoptosis inducer 10 

Apoptosis inducer 10 is a potent apoptosis inducer. Apoptosis inducer 10 shows antiproliferative effect. Apoptosis inducer 10 induces apoptosis in HeLa cancer cells via a mitochondria-dependent endogenous pathway^[1].

Apoptosis inducer 10 (compound 11) shows cytotoxic activity with IC₅₀s of 7.39, 63.20, 15.28, 15.38, 12.07 µM for HeLa, HL-7702, A549, PC-3, MCF-7 cells, respectively^[1].
Apoptosis inducer 10 (2.5, 5, 10 µM) inhibits tumor cell colony formation in A549, HeLa, PC-3 and MCF-7 cells^[1].
Apoptosis inducer 10 (2.5, 5, 10 µM; 48 h) induces apoptosis in HeLa cells in a dose dependent manner^[1].
Apoptosis inducer 10 (0, 2.5, 5, 10, 20 µM; 72 h) decreases the ratio to the expression of Bcl-2 and Bax in HeLa cells and resultes in the release of cytochrome c, thereby activates caspase-9 and caspase-3, and cleaved PARP proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

430.67

C₂₇H₄₆N₂O₂

2379310-39-9

O=C(N1CCC(N(C)C)CC1)/C=C(C)/CC[C@@H]2C(CC[C@]3([H])C(C)(C)[C@H](O)CC[C@@]23C)=C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhang S, et al. Incorporation of amino moiety to alepterolic acid improve activity against cancer cell lines: Synthesis and biological evaluation. Bioorg Chem. 2020 May;98:103756.  [Content Brief]