2. Apoptosis
  3. Apoptosis
  4. Apoptosis inducer 12

Apoptosis inducer 12 (Compound 3z) is an apoptosis inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 12 can be used for the research of cancer.

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Apoptosis inducer 12 Chemical Structure

Apoptosis inducer 12 Chemical Structure

CAS No. : 1971096-01-1

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Apoptosis inducer 12 Related Antibodies

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Description

Apoptosis inducer 12 (Compound 3z) is an apoptosis inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 12 can be used for the research of cancer[1].

In Vitro

Apoptosis inducer 12 (Compound 3z; 72 h) shows antiproliferative activity against nine human cancer cell types (leukemia, non-small-cell lung, colon, central nervous system, melanoma, ovarian, renal, prostate and breast) with GI50 of 0.24-96.6 μM. leukemia and prostate cell lines are particularly responsive to treatment with Apoptosis inducer 12, with GI50 values of 0.30-0.65 μM and 0.43-0.84 μM, respectively[1].
Apoptosis inducer 12 (0.5-10 μM; 24 h) blocks the cell cycle in metaphase in A549, CCRF-CEM and VL51 cells[1].
Apoptosis inducer 12 (0.5-5 μM; 48 h) induces apoptosis in A549, CCRF-CEM and VL51 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 12 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: A549, CCRF-CEM and VL51
Concentration: 0.5, 1, 5 and 10 μM
Incubation Time: 24 h
Result: Induced a block in G2/M accompanied by a strong decrease in S phase cells.

Apoptosis Analysis[1]

Cell Line: A549, CCRF-CEM and VL51
Concentration: 0.5, 1 and 5 μM
Incubation Time: 48 h
Result: Induced massive apoptosis in a dose-dependent manner.
Molecular Weight

475.54

Formula

C27H29N3O5
CAS No.
SMILES

COC1=CC(C2=C3CCCC4=C(C3=CN2CC5=CC(N)=C(C=C5)OC)ON=C4)=CC(OC)=C1OC
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References
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Apoptosis inducer 12 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 121971096-01-1Apoptosis inducer12Apoptosis inducer-12ApoptosisMDA-MB-435BT-549NCI–H522A549CCRF-CEMVL51Inhibitorinhibitorinhibit

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