2. Apoptosis
  3. Apoptosis
  4. Apoptosis inducer 20

Apoptosis inducer 20 (12) causes G2/M cell cycle arrest and induction of apoptosis via caspase 3/7 activation, which occurred during M arrest. Apoptosis inducer 20 is a novel indolic benzenesulfonamide with anti-proliferative effect against a broad panel of cancer cell lines, which is proming for research of new anti-mitotic agents.

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Apoptosis inducer 20 Chemical Structure

Apoptosis inducer 20 Chemical Structure

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Apoptosis inducer 20 Related Antibodies

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Description

Apoptosis inducer 20 (12) causes G2/M cell cycle arrest and induction of apoptosis via caspase 3/7 activation, which occurred during M arrest. Apoptosis inducer 20 is a novel indolic benzenesulfonamide with anti-proliferative effect against a broad panel of cancer cell lines, which is proming for research of new anti-mitotic agents[1].

In Vitro

Apoptosis inducer 20 inhibits cell growth activity in different cancer cell lines. The melanoma cell-line MelMet5 is the most sensitive cell-line, followed by HeLa[1].
Apoptosis inducer 20 (100 nM, 24 h) causes G2/M cell cycle arrest and induction of apoptosis via caspase 3/7 activation in MES-SA cells[1].

Antiproliferative IC50 values of active sulfonamides on HeLa, MCF7, BT-474, MDA-MB468, MES-SA, HT-1080, MelMet5, A375, WM-1366, and Caki1 cancer cell lines[1]

药代动力学分析[1]

HeLa MCF7 BT-474 MDA-MB468 MES-SA HT-1080 MelMet5 A375 WM-1366 Caki1
12 11.0 13.7 68.3 13.0 8.9 9.9 8.9 22.1 52.8 56.2

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 20 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: MES-SA cells (human uterine sarcoma)
Concentration: 100 nM
Incubation Time: 24 h
Result: Increased the percentage of cells in the G2/M ensemble from 13.3 % to 83.6-89.7 % at the expense of the S (from 27 % to 6-9 %) and G1 phases (from 60 % to 4-7 %) in MES-SA cells.

Apoptosis Analysis[1]

Cell Line: MES-SA cells (human uterine sarcoma)
Concentration: 100 nM
Incubation Time: 3 days
Result: Induced caspase activation and therefore cell apoptosis in a time-dependent manner in MES-SA cells.

Immunofluorescence[1]

Cell Line: MES-SA cells (human uterine sarcoma)
Concentration: 10 nM
Incubation Time: 24 h
Result: Induced microtubule nonfunction, depolymerization and the cell loseed its characteristic shape in MES-SA cells.
Molecular Weight

415.46

Formula

C20H21N3O5S
SMILES

CN1C=CC2=C1C=CC(N(CC#N)S(C3=CC(OC)=C(OC)C(OC)=C3)(=O)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Apoptosis inducer 20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 20Apoptosis inducer20Apoptosis inducer-20ApoptosisG2/M cell cyclecaspase 3/7 activationindolic benzenesulfonamidecancer cell linesanti-mitoticInhibitorinhibitorinhibit

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