2. Apoptosis Immunology/Inflammation
  3. Apoptosis Pyroptosis
  4. Apoptosis inducer 36

Apoptosis inducer 36 (Compound 42) exhibits anti-leukemic activity through reduction of leukemia stem cells (LSCs) and induction of differentiation. Apoptosis inducer 36 inhibits the proliferation of AML cells, arrests cell cycle at G1 phase, and induces PANoptosis including apoptosis, pyroptosis and necrosis. Prodrug of apoptosis inducer 36 exhibits orally active antitumor efficacy in mouse model.

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Apoptosis inducer 36 Chemical Structure

Apoptosis inducer 36 Chemical Structure

CAS No. : 2831492-41-0

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Description

Apoptosis inducer 36 (Compound 42) exhibits anti-leukemic activity through reduction of leukemia stem cells (LSCs) and induction of differentiation. Apoptosis inducer 36 inhibits the proliferation of AML cells, arrests cell cycle at G1 phase, and induces PANoptosis including apoptosis, pyroptosis and necrosis. Prodrug of apoptosis inducer 36 exhibits orally active antitumor efficacy in mouse model[1].

Molecular Weight

392.65

Formula

C23H40O3Si
CAS No.
SMILES

[H][C@@]12CC(C(O[C@@H]1CC[C@@]3([C@H](CC[C@]32[H])O[Si](C(C)C)(C(C)C)C(C)C)C)=O)=C
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Room temperature in continental US; may vary elsewhere.
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Apoptosis inducer 36 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 362831492-41-0Apoptosis inducer36Apoptosis inducer-36ApoptosisPyroptosisAMLPANoptosisanti-leukemicorally activeInhibitorinhibitorinhibit

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