2. Immunology/Inflammation Apoptosis
  3. Galectin Apoptosis
  4. Apoptosis inducer 8

Apoptosis inducer 8 (Compound 7c) is a galectin-1 (gal-1) mediated apoptosis-inducing agent against global major leading lung cancer burden. Apoptosis inducer 8 significantly reduced the gal-1 protein level. Apoptosis inducer 8 is also a PET imaging agent.

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Apoptosis inducer 8 Chemical Structure

Apoptosis inducer 8 Chemical Structure

CAS No. : 2470024-51-0

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Apoptosis inducer 8 Related Antibodies

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Description

Apoptosis inducer 8 (Compound 7c) is a galectin-1 (gal-1) mediated apoptosis-inducing agent against global major leading lung cancer burden. Apoptosis inducer 8 significantly reduced the gal-1 protein level. Apoptosis inducer 8 is also a PET imaging agent[1].

IC50 & Target

Galectin-1

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.63 μM
Compound: 74
Anticancer activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Anticancer activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34146913]
MCF7 IC50
1.3 μM
Compound: 74
Anticancer activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Anticancer activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34146913]
NCI-H460 IC50
0.99 μM
Compound: 74
Anticancer activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Anticancer activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34146913]
In Vitro

Apoptosis inducer 8 (Compound 7c) exhibits an excellent growth inhibition against A-549, NCI-H460, MCF-7 and MDA-MB-23 cells with IC50 values of 0.63 ± 0.21, 0.99 ± 0.01, 1.3 ± 0.18 and 0.94 ± 0.02 µM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 8 Related Antibodies
Molecular Weight

507.97

Formula

C29H22ClN5O2
CAS No.
SMILES

OC1=CC=CC(N2N=NC(COC3=CC=C(C4=NC5=CC(Cl)=CC=C5N4CC6=CC=CC=C6)C=C3)=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Apoptosis inducer 8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 82470024-51-0Apoptosis inducer8Apoptosis inducer-8GalectinApoptosisMCF-7 and MDA-MB-231HaCaTA-549NCI-H460Inhibitorinhibitorinhibit

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