Apramycin-d₇ acetate  (Synonyms: Nebramycin II-d₇ acetate)

Apramycin-d₇ (acetate) (Nebramycin II-d₇ (acetate)) is a deuterium labeled compound.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C₂₁H₃₄D₇N₅O₁₁.xC₂H₄O₂

Solid

Off-white to light yellow

O[C@]1([C@@]2([C@@]([H])(O[C@H](O[C@H]3O[C@H](C([2H])(O)[2H])[C@@H](N)[C@]([2H])(O)[C@]3(O)[2H])[C@H]1NC)C[C@@H](N)[C@@H](O[C@H]4[C@]([2H])(O)[C@@]([2H])(O)[C@H](N)C[C@@H]4N)O2)[H])[2H].CC(O)=O.[x]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.  [Content Brief]