AR-C117977

Cat. No.: HY-114602: FAQs
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AR-C117977 is a potent monocarboxylate transporter (MCT1) inhibitor. AR-C117977 prolongs the survival of skin and heart sllograft. AR-C117977 inhibits the development of transplant arteriosclerosis in aortic allografts partially, but was unable to inhibit alloantibody production after transplantation. AR-C117977 shows potent immunosuppressive properties in vivo effectively preventing acute but not chronic allograft rejection in the mouse.

For research use only. We do not sell to patients.

AR-C117977 Chemical Structure

CAS No. : 216685-07-3

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Description	AR-C117977 is a potent monocarboxylate transporter (MCT1) inhibitor. AR-C117977 prolongs the survival of skin and heart sllograft. AR-C117977 inhibits the development of transplant arteriosclerosis in aortic allografts partially, but was unable to inhibit alloantibody production after transplantation. AR-C117977 shows potent immunosuppressive properties in vivo effectively preventing acute but not chronic allograft rejection in the mouse^[1].
Molecular Weight	468.63
Formula	C₂₅H₂₈N₂O₃S₂
CAS No.	216685-07-3
SMILES	O=C1N(CC(C)C)C2=C(C(SCCCO)=C(CC3=C4C=CC=CC4=CC=C3)S2)C(N1C)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Bueno V, et al. The specific monocarboxylate transporter (MCT1) inhibitor, AR-C117977, a novel immunosuppressant, prolongs allograft survival in the mouse. Transplantation. 2007 Nov 15;84(9):1204-7. [Content Brief]

AR-C117977 Related Classifications

Inflammation/Immunology

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AR-C117977216685-07-3Monocarboxylate Transporterskin and heart sllograftimmunosuppressive propertieInhibitorinhibitorinhibit

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AR-C117977

AR-C117977 Related Antibodies

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