AR-R17779 hydrochloride

Name: AR-R17779 hydrochloride
Brand: MedChemExpress
SKU: HY-135483A
Rating: 4.5 (1 reviews)

Cat. No.: HY-135483A Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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AR-R17779 hydrochloride is a potent and selective full agonist of nAChR, with K_is of 92 and 16000 nM for α7 and α4β2 subtype, respectively. AR-R17779 hydrochloride can improve learning and memory in rats. AR-R17779 hydrochloride also has anxiolytic activity. AR-R17779 hydrochloride can reduce inflammation by activating antiinflammatory cholinergic (vagal) pathways.

For research use only. We do not sell to patients.

AR-R17779 hydrochloride Chemical Structure

CAS No. : 178419-42-6

Size	Price	Stock	Quantity
5 mg	USD 255	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC50: 92 nM (α7-nAChR)^[1]

In Vitro

AR-R17779 is 5-fold more potent and 35000-fold more selective than (-)-nicotine for the α7 nicotinic receptor^[1].
AR-R17779 (200 nM; 24 h) inhibits the LPS-induced TNF production in macrophages^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AR-R17779 (1-5 mg/kg; i.p. twice a day for 7 d) ameliorates arthritis, reduces synovial inflammation, delays onset of disease and protects against joint destruction^[3].
AR-R17779 (1-10 mg/kg; s.c. for 3 weeks) improves learning in two radial-arm maze tasks and reverses working memory impairment caused by fimbria-fornix sections in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male DBA/1 mice (8-10 weeks) were subjected to unilateral cervical vagotomy or sham surgery, after which arthritis was induced with type II collagen^[3]
Dosage:	1, 2.5, 5 mg/kg
Administration:	I.p. twice daily from day 20 until day 26
Result:	Ameliorated arthritis and delayed onset of disease. Reduced erosive disease, cartilage degradation and synovial inflammation. Reduced TNFα levels in plasma and synovial tissue.

Molecular Weight

218.68

Formula

C₉H₁₅ClN₂O₂

CAS No.

178419-42-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1)O[C@@]21CN3CCC2CC3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 32 mg/mL (146.33 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5729 mL	22.8645 mL	45.7289 mL
5 mM	0.9146 mL	4.5729 mL	9.1458 mL
10 mM	0.4573 mL	2.2864 mL	4.5729 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (277 KB) SDS (555 KB)

COA (252 KB)

Handling Instructions (2659 KB)

References

[1]. Mullen G, et, al. (-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. J Med Chem. 2000 Nov 2;43(22):4045-50. [Content Brief]

[2]. Levin ED, et, al. AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats. Behav Pharmacol. 1999 Nov;10(6-7):675-80. [Content Brief]

[3]. Maanen MA, et, al. Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice. Arthritis Rheum. 2009 Jan;60(1):114-22. [Content Brief]

[4]. Lopes F, et, al. Involvement of Mast Cells in α7 Nicotinic Receptor Agonist Exacerbation of Freund's Complete Adjuvant-Induced Monoarthritis in Mice. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.5729 mL	22.8645 mL	45.7289 mL	114.3223 mL
	5 mM	0.9146 mL	4.5729 mL	9.1458 mL	22.8645 mL
	10 mM	0.4573 mL	2.2864 mL	4.5729 mL	11.4322 mL
	15 mM	0.3049 mL	1.5243 mL	3.0486 mL	7.6215 mL
	20 mM	0.2286 mL	1.1432 mL	2.2864 mL	5.7161 mL
	25 mM	0.1829 mL	0.9146 mL	1.8292 mL	4.5729 mL
	30 mM	0.1524 mL	0.7621 mL	1.5243 mL	3.8107 mL
	40 mM	0.1143 mL	0.5716 mL	1.1432 mL	2.8581 mL
	50 mM	0.0915 mL	0.4573 mL	0.9146 mL	2.2864 mL
	60 mM	0.0762 mL	0.3811 mL	0.7621 mL	1.9054 mL
	80 mM	0.0572 mL	0.2858 mL	0.5716 mL	1.4290 mL
	100 mM	0.0457 mL	0.2286 mL	0.4573 mL	1.1432 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.