2. Anti-infection
  3. Bacterial
  4. Arcopilin A

Arcopilin A (compound Arcopilin A(1))is an antibacterial agent. Arcopilin A has weak inhibitory effects on fungal pathogens and Gram-positive bacteria, with IC50 values of 8.9 μg/mL and 14 μg/mL for cells KB-3-1 and L929, but it can effectively destroy preformed biofilms of Staphylococcus aureus. Arcopilin A can enhance the activities of gentamicin (GM; HY-K1050) and vancomycin (Vac; HY-B0671) by 115 and 31 times, respectively.

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Arcopilin A Chemical Structure

Arcopilin A Chemical Structure

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Arcopilin A Related Antibodies

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Description

Arcopilin A (compound Arcopilin A(1))is an antibacterial agent. Arcopilin A has weak inhibitory effects on fungal pathogens and Gram-positive bacteria, with IC50 values of 8.9 μg/mL and 14 μg/mL for cells KB-3-1 and L929, but it can effectively destroy preformed biofilms of Staphylococcus aureus. Arcopilin A can enhance the activities of gentamicin (GM; HY-K1050) and vancomycin (Vac; HY-B0671) by 115 and 31 times, respectively[1].

In Vitro

Arcopilin A disruptes preformed biofilms by approximately 50-60% in the concentration range of 15.6-250 μg/mL, and can also inhibit the growth of Staphylococcus aureus at concentrations as low as 3.9 and 7.8 μg/mL[1].
Arcopilin A has an MIC value of 66.7 μg/mL against B.subtilis DSM 10, S.aureus DSM 346, S.pombe DSM70572, C.albicans DSM 1665, and M.hiemalis DSM 2656, and an MIC value of 31.3 μg/mL against S.aureus DSM 1104[1].
Arcopilin A (3.9-31.1 μg/mL) reduces biofilm metabolic activity in a dose-dependent manner[1].
Arcopilin A (2-7.8 μg/mL) inhibits the growth of Staphylococcus aureus DSM 1104 planktonic cells[1].
Arcopilin A (3.9-7.8 μg/mL, 24 h) when used with GM (HY-K1050) and Vac (HY-B0671) have a synergistic effect on Staphylococcus aureus DSM 1104 planktonic cells. The MIC values of the established antibiotics were reduced from 15.6 to 0.13 μg/mL and from 2 to 0.065 μg/mL respectively. The combined treatment significantly increased the potency of GM (HY-K1050) and Vac (HY-B0671) by 115-fold and 31-fold, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Arcopilin A Related Antibodies
Molecular Weight

369.45

Formula

C22H27NO4
SMILES

CC([C@@H](C[C@H](C[C@@H](C(C1=C(/C(NC1=O)=C/C2=CC=CC=C2)O)=O)C)C)C)=O
Structure Classification
Initial Source

Arcopilus navicularis CCF 3252T
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Arcopilin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Arcopilin ABacterialDamage to cell membranesGentamicinVancomycinInhibitorinhibitorinhibit

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