2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Reactive Oxygen Species Endogenous Metabolite
  4. Argininosuccinic acid disodium

Argininosuccinic acid disodium 

Cat. No.: HY-113149A Purity: ≥96.0%
COA Handling Instructions

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Argininosuccinic acid disodium participates in the fourth step of the urea cycle and is cleaved into arginine and fumarate by argininosuccinate lyase (ASL). Argininosuccinic acid disodium reduces reduced glutathione (GSH) concentrations and increases reactive oxygen species production in the cerebral cortex and striatum. Argininosuccinic acid disodium causes lipid peroxidation and protein oxidation and also induces oxidative stress in the developing rat brain.

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Argininosuccinic acid disodium Chemical Structure

Argininosuccinic acid disodium Chemical Structure

CAS No. : 918149-29-8

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1 mg USD 200 In-stock
5 mg USD 590 In-stock
10 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Argininosuccinic acid disodium participates in the fourth step of the urea cycle and is cleaved into arginine and fumarate by argininosuccinate lyase (ASL). Argininosuccinic acid disodium reduces reduced glutathione (GSH) concentrations and increases reactive oxygen species production in the cerebral cortex and striatum. Argininosuccinic acid disodium causes lipid peroxidation and protein oxidation and also induces oxidative stress in the developing rat brain[1][2].

Molecular Weight

334.24

Formula

C10H16N4Na2O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](N)CCCNC(N[C@H](C(O[Na])=O)CC(O[Na])=O)=N)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (149.59 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9919 mL 14.9593 mL 29.9186 mL
5 mM 0.5984 mL 2.9919 mL 5.9837 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥96.0%

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.9919 mL 14.9593 mL 29.9186 mL 74.7966 mL
5 mM 0.5984 mL 2.9919 mL 5.9837 mL 14.9593 mL
10 mM 0.2992 mL 1.4959 mL 2.9919 mL 7.4797 mL
15 mM 0.1995 mL 0.9973 mL 1.9946 mL 4.9864 mL
20 mM 0.1496 mL 0.7480 mL 1.4959 mL 3.7398 mL
25 mM 0.1197 mL 0.5984 mL 1.1967 mL 2.9919 mL
30 mM 0.0997 mL 0.4986 mL 0.9973 mL 2.4932 mL
40 mM 0.0748 mL 0.3740 mL 0.7480 mL 1.8699 mL
50 mM 0.0598 mL 0.2992 mL 0.5984 mL 1.4959 mL
60 mM 0.0499 mL 0.2493 mL 0.4986 mL 1.2466 mL
80 mM 0.0374 mL 0.1870 mL 0.3740 mL 0.9350 mL
100 mM 0.0299 mL 0.1496 mL 0.2992 mL 0.7480 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Argininosuccinic acid disodium Related Classifications

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Keywords:

Argininosuccinic acid disodium918149-29-8Reactive Oxygen SpeciesEndogenous MetaboliteInhibitorinhibitorinhibit

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