Argipressin acetate  (Synonyms: Arg8-vasopressin acetate; AVP acetate)

Argipressin (Arg8-vasopressin) (acetate) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a K_d value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1^[1][2][3][4].

Argipressin (Arg8-vasopressin) (acetate) induces proliferation and prevented cytokine-induced apoptosis in rodent and human beta-cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Argipressin (Arg8-vasopressin) (acetate) (25 nmol/kg bw; intraperitoneal injection; once) significantly reduces overall AUC glucose values，but not increases insulin levels in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1144.28

C₄₈H₆₉N₁₅O₁₄S₂

129979-57-3

CYFQNCPRG-NH2 (Disulfide bridge: Cys1-Cys6)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Shruti Mohan, et al. Vasopressin receptors in islets enhance glucose tolerance, pancreatic beta-cell secretory function, proliferation and survival. Biochimie.  [Content Brief]

  [2]. Thibonnier M, et al. Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cells. Endocrinology. 1991 Dec;129(6):2845-56.  [Content Brief]

  [3]. Moriya T, et al. Vasopressin-induced intracellular Ca²⁺ concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Res. 2012 Nov 5;1483:1-12.  [Content Brief]

  [4]. Keun Suk Park, et al. Role of vasopressin in current anesthetic practice. Korean J Anesthesiol. 2017 Jun; 70(3): 245–257.  [Content Brief]