2. Membrane Transporter/Ion Channel
  3. CFTR
  4. ARN23765

ARN23765 is a corrector for F508del-CFTR with an EC50 of 38 pM in human bronchial epithelial cells. ARN23765 improves the maturation and function of F508del-CFTR on the cell membrane, affects the ions transport and secretion, and corrects the pathological mechanism of cystic fibrosis (CF).

For research use only. We do not sell to patients.

ARN23765 Chemical Structure

ARN23765 Chemical Structure

CAS No. : 2244458-40-8

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Description

ARN23765 is a corrector for F508del-CFTR with an EC50 of 38 pM in human bronchial epithelial cells. ARN23765 improves the maturation and function of F508del-CFTR on the cell membrane, affects the ions transport and secretion, and corrects the pathological mechanism of cystic fibrosis (CF)[1].

Molecular Weight

615.50

Formula

C30H22F5N3O6
CAS No.
SMILES

OC(C1=CC=C(C=C1)O[C@H]2CCCC3=C2N(N=C3C(F)(F)F)C4=CC(C(N(C)C5=CC6=C(OC(F)(F)O6)C=C5)=O)=CC=C4)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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ARN23765 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARN237652244458-40-8ARN 23765ARN-23765CFTRCystic fibrosis transmembrane conductance regulatorcystic fibrosisCFInhibitorinhibitorinhibit

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