2. Metabolic Enzyme/Protease
  3. Acyltransferase
  4. AS-183

AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC50=0.94 µM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC50 values ​​of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia.

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AS-183 Chemical Structure

AS-183 Chemical Structure

CAS No. : 147317-12-2

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AS-183 Related Antibodies

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ACAT1 ACAT2 MGAT2 ACAT

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Description

AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC50=0.94 µM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC50 values ​​of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia[1].

Cellular Effect
Cell Line Type Value Description References
Caco-2 IC50
25.5 μM
Compound: 101; AS-183
Reduction in cholesteryl ester synthesis in human Caco-2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
Reduction in cholesteryl ester synthesis in human Caco-2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
[PMID: 36473091]
HepG2 IC50
18.1 μM
Compound: 101; AS-183
Reduction in cholesteryl ester synthesis in human HepG2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
Reduction in cholesteryl ester synthesis in human HepG2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
[PMID: 36473091]
THP-1 IC50
34.5 μM
Compound: 101; AS-183
Reduction in cholesteryl ester synthesis in human THP-1 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
Reduction in cholesteryl ester synthesis in human THP-1 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis
[PMID: 36473091]
Molecular Weight

310.47

Formula

C19H34O3
CAS No.
SMILES

O=C1C(O)(OC(C(CC(CC(CC(CC)C)C)C)C)=C1C)C
Structure Classification
Initial Source

Scedosporium sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AS-183 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AS-183147317-12-2AS183AS 183AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseACATinhibitoratherosclerosishypercholesterolemiaHepG2 cellsCaCo2 cellsTHP-1 cellsInhibitorinhibit

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