2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial Nucleoside Antimetabolite/Analog Antibiotic
  4. Ascamycin

Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against Xanthomonas species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei, respectively.

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Ascamycin Chemical Structure

Ascamycin Chemical Structure

CAS No. : 91432-48-3

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Ascamycin Related Antibodies

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Description

Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against Xanthomonas species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei, respectively[1][2][3].

IC50 & Target

MIC: 0.4 μg/mL (Xanthomonas citri), 12.5 μg/mL (Xanthomonas oryzae) and 12.5 μg/mL (Mycobacterium phlei)[1]
In Vitro

The Ascamycin has C2-chloroadenine as the base on C-1' which lacks the chlorine[1]. Ascamycin has a selective antibacterial activity against Xanthomonas species. When Ascamycin is dealanylated, Dealanylascamycin shows a broad antibacterial activity against various Gram-negative and Gram-positive bacteria. Xanthomonas citri is susceptible to Ascamycin by virtue of the Ascamycin-dealanylating enzyme on the cell surface[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ascamycin Related Antibodies
Molecular Weight

451.84

Formula

C13H18ClN7O7S
CAS No.
SMILES

O[C@@H]([C@H]([C@H](N1C=NC2=C(N=C(Cl)N=C21)N)O3)O)[C@H]3COS(=O)(NC([C@@H](N)C)=O)=O
Structure Classification
Initial Source

Streptomyces sp
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ascamycin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ascamycin91432-48-3BacterialNucleoside Antimetabolite/AnalogAntibioticAdenosineantibiotic5'-O-sulfonamideribonucleosideaminopeptidaseantimicrobialXanthomonasInhibitorinhibitorinhibit

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