Aselizumab  (Synonyms: HuDreg-55)

Aselizumab (HuDreg-55) is an humanized IgG4 mAb against L-selectin. However, L-selectin (CD62L) is a cell adhesion molecule expressed on circulating neutrophils. It regulates migrating cells to chemotaxis towards the site of injury. Aselizumab may be account for a high rate of infections and leucopenia after truma^[1][2].

Human IgG4 kappa

Human IgG4 (S228P) kappa, Isotype Control

Humanized

L-selectin^[1][2]

Aselizumab can disulfide with human-mouse monoclonal HuDreg-55 light chain to form dimer^[1].
Aselizumab (5-500 ng/mL; 25 min) blocks L-selectin-dependent adhesion of human lymphocytes to high endothelial venules in frozen sections of lymph nodes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aselizumab (10 mg/kg; i.v.; single dose) shows terminal elimination half-lives at 12.0 days in rhesus monkeys^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

395639-53-9

Liquid

Colorless to light yellow

[Aselizumab]

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Human IgG4 kappa

• [1]. Seekamp A, et al. The effect of anti-L-selectin (aselizumab) in multiple traumatized patients--results of a phase II clinical trial. Crit Care Med. 2004 Oct;32(10):2021-8.  [Content Brief]

  [2]. Rahman I, et al. L-selectin regulates human neutrophil transendothelial migration. J Cell Sci. 2021 Feb 8;134(3):jcs250340.  [Content Brief]

  [3]. Co MS, et al. Properties and pharmacokinetics of two humanized antibodies specific for L-selectin. Immunotechnology. 1999 Mar;4(3-4):253-66.  [Content Brief]