2. Peptides
  3. Peptide and Derivatives
  4. β-Amyloid and Tau Peptides
  5. β-Amyloid Peptides
  6. [Asn23]-beta-Amyloid (1-42), iowa mutation

[Asn23]-beta-Amyloid (1-42), iowa mutation is a biological active peptide. (Several mutations in the beta amyloid precursor gene cause autosomal dominant Alzheimer's Disease in a number of kindreds. The Iowa mutation, where Asp 23 is replaced with Asn, is associated with severe cerebral amyloid beta-protein angiopathy (CAA). The affected individuals share a missense mutation in APP at position 694. The mutated beta-amyloid peptide aggregates more rapidly and forms toxic fibrils.)

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[Asn23]-beta-Amyloid (1-42), iowa mutation Chemical Structure

[Asn23]-beta-Amyloid (1-42), iowa mutation Chemical Structure

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[Asn23]-beta-Amyloid (1-42), iowa mutation Related Antibodies

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Description

[Asn23]-beta-Amyloid (1-42), iowa mutation is a biological active peptide. (Several mutations in the beta amyloid precursor gene cause autosomal dominant Alzheimer's Disease in a number of kindreds. The Iowa mutation, where Asp 23 is replaced with Asn, is associated with severe cerebral amyloid beta-protein angiopathy (CAA). The affected individuals share a missense mutation in APP at position 694. The mutated beta-amyloid peptide aggregates more rapidly and forms toxic fibrils.)

Molecular Weight

4513.05

Formula

C203H312N56O59S
Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asn-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
Sequence Shortening

DAEFRHDSGYEVHHQKLVFFAENVGSNKGAIIGLMVGGVVIA
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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[Asn23]-beta-Amyloid (1-42), iowa mutation Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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[Asn23]-beta-Amyloid (1-42), iowa mutationOthersInhibitorinhibitorinhibit

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