ASP1126

Cat. No.: HY-125881: FAQs
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ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC₅₀ values of 7.12 nM, 517 nM for hS1P₁ and hS1P₃, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile.

For research use only. We do not sell to patients.

ASP1126 Chemical Structure

CAS No. : 1228580-11-7

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

EC50: 7.12 nM (hS1P₁), 517 nM (hS1P₃)^[1].

In Vivo

ASP1126 (1 and 5 mg/kg, orally once daily for 14 days) significantly prolongs allograft survival^[1].
ASP1126 in combination with 0.02 mg/kg tacrolimus notably improves graft survival time^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	ACI and Lewis rats aged 6 weeks were used as cardiac donors and recipients, respectively^[1].
Dosage:	0.2 mg/kg, 1 mg/kg, 5 mg/kg.
Administration:	Orally once daily for 14 days.
Result:	Significantly prolonged allograft survival (median survival time [MST] =9; 8 days at 1 and 5 mg/kg, respectively, compared with 6 days in the vehicle group).

Molecular Weight

581.93

Formula

C₂₆H₂₆ClF₆NO₅

CAS No.

1228580-11-7

SMILES

O=C(C1CCN(CC2=CC3=CC=C(OCC4=CC=C(OCC(F)(F)F)C(C(F)(F)F)=C4)C=C3OC2)CC1)O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Okimoto A, et al. ASP1126, a Novel Sphingosine-1-Phosphate-Selective Agonist With a Favorable Safety Profile, Prolongs Allograft Survival in Rats and Nonhuman Primates in Combination With Tacrolimus With a Broad Safety Margin for Bradycardia. Transplant P [Content Brief]

ASP1126 Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASP11261228580-11-7ASP 1126ASP-1126LPL ReceptorLysophospholipid ReceptorInhibitorinhibitorinhibit

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