Ataprost  (Synonyms: ONO 41483)

Ataprost (ONO 41483) is an orally active Carboprostacyclin (HY-112322) analogue. Ataprost exhibits 2.6 times more active than Carboprostacyclin in inhibiting ADP-induced platelet aggregation in vitro. Ataprost has the ability to relieve coronary spasm^[1].

Platelet aggregation^[1]

Ataprost inhibits platelet aggregation in human and baboon platelet rich plasma (PRP) with ED₅₀s of 1.91 ng/mL and 4.38 ng/mL, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ataprost (50-200 μg/kg; p.o.; single dose) inhibits platelet aggregation with an ED₅₀ value of 87 μg/kg in baboon^[1].
Ataprost (i.v.; single dose) inhibits platelet aggregation with an ED₅₀ value of 3.2 μg/kg in baboon^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

348.48

C₂₁H₃₂O₄

83997-19-7

O[C@@H](C1CCCC1)/C=C/[C@@H]2[C@](C/3)([H])[C@](CC3=C/CCCC(O)=O)([H])C[C@H]2O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Adaikan PG, et al. Inhibition of platelet aggregation and reversal of vasopressin-induced ECG changes by a carboprostacyclin analogue, ONO 41483, in primates. Prostaglandins Leukot Med. 1982 Sep;9(3):307-20.  [Content Brief]