ATB-343

Cat. No.: HY-15033: FAQs
Data Sheet Handling Instructions

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ATB-343 is a derivative of Indomethacin that releases H2S. H2S has cytoprotective and anti-inflammatory effects, inhibiting leukocyte adhesion to vascular endothelium and leukocyte migration to inflammatory sites. ATB-343 can be used to suppress respiratory infections.

For research use only. We do not sell to patients.

ATB-343 Chemical Structure

CAS No. : 1000700-26-4

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	3294.4 μM Compound: 15	Cytotoxicity against human HepG2 cells assessed as reduction in cell survival after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell survival after 24 hrs by MTT assay	[PMID: 28646655]
L02	IC₅₀	337.2 μM Compound: 15	Cytotoxicity against human LO2 cells assessed as reduction in cell survival after 24 hrs by MTT assay Cytotoxicity against human LO2 cells assessed as reduction in cell survival after 24 hrs by MTT assay	[PMID: 28646655]

Molecular Weight

566.11

Formula

C₂₈H₂₀ClNO₄S₃

CAS No.

1000700-26-4

SMILES

O=C(CC1=C(C)N(C(C2=CC=C(C=C2)Cl)=O)C3=C1C=C(C=C3)OC)OC4=CC=C(C(SS5)=CC5=S)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li M, et al. Syntheses, toxicities and anti-inflammation of H2S-donors based on non-steroidal anti-inflammatory drugs. Eur J Med Chem. 2017 Sep 29;138:51-65. [Content Brief]

[2]. Methods for treating viral infections using hydrogen sulfide (H2S) donors. United States, US20160058779 A1 2016-03-03.

ATB-343 Related Classifications

Inflammation/Immunology Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATB-3431000700-26-4ATB343ATB 343OthersAnti-inflammatorywhite blood cellsadhesion to blood vesselsInhibitorinhibitorinhibit

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