2. GPCR/G Protein Neuronal Signaling
  3. MCHR1 (GPR24)
  4. ATC0175 free base

ATC0175 (free base) is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH-R1) with an IC50 value of 3.4 nM, as well as good selectivity over the Y5 and the α2A receptors. ATC0175 (free base) is promising for research of obesity.

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ATC0175 free base Chemical Structure

ATC0175 free base Chemical Structure

CAS No. : 509118-03-0

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ATC0175 free base Related Antibodies

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Description

ATC0175 (free base) is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH-R1) with an IC50 value of 3.4 nM, as well as good selectivity over the Y5 and the α2A receptors. ATC0175 (free base) is promising for research of obesity[1].

Cellular Effect
Cell Line Type Value Description References
CHO IC50
8.28 nM
Compound: ATC-0175
Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assay
Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assay
[PMID: 31678007]
COS-1 IC50
260 nM
Compound: 28 (ATC-O175)
Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells
Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells
[PMID: 16002290]
COS-1 IC50
2700 nM
Compound: 28 (ATC-O175)
Inhibitory activity against neuropeptide Y receptor type 5 by using [125I]PYY as radioligand expressed in COS-1 cells
Inhibitory activity against neuropeptide Y receptor type 5 by using [125I]PYY as radioligand expressed in COS-1 cells
[PMID: 16002290]
HEK293 IC50
3.4 nM
Compound: 28 (ATC-O175)
Inhibitory activity against human CA-MCH-R1 (Melanin-concentrating hormone receptor 1) by using [125I](Phe13,Tyr19)MCH as radioligand expressed in HEK293 cells
Inhibitory activity against human CA-MCH-R1 (Melanin-concentrating hormone receptor 1) by using [125I](Phe13,Tyr19)MCH as radioligand expressed in HEK293 cells
[PMID: 16002290]
HEK293 IC50
7.2 nM
Compound: ATC-0175
Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay
Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay
[PMID: 19773162]
Molecular Weight

425.47

Formula

C23H25F2N5O
CAS No.
SMILES

CN(C1=NC(N[C@H]2CC[C@H](CC2)NC(C3=CC(F)=C(C=C3)F)=O)=NC4=C1C=CC=C4)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ATC0175 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATC0175509118-03-0ATC 0175ATC-0175MCHR1 (GPR24)Melanin concentrating hormone receptor 1MCH-R1Y5α2A receptorsobesityInhibitorinhibitorinhibit

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