2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. ATM Inhibitor-11

ATM Inhibitor-11 (Compound 1) is an inhibitor for ATM with an IC500 of 0.32 nM. ATM Inhibitor-11 inhibits the KAP1 phosphorylation with an IC500 of 0.97 nM. ATM Inhibitor-11 exhibits high exposure in the brain, heart and plasma of ICR mouse. ATM Inhibitor-11 exhibits anti-tumor efficacy in NCI-H441 xenograft mouse model.

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ATM Inhibitor-11 Chemical Structure

ATM Inhibitor-11 Chemical Structure

CAS No. : 2878473-51-7

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ATM Inhibitor-11 Related Antibodies

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Description

ATM Inhibitor-11 (Compound 1) is an inhibitor for ATM with an IC500 of 0.32 nM. ATM Inhibitor-11 inhibits the KAP1 phosphorylation with an IC500 of 0.97 nM. ATM Inhibitor-11 exhibits high exposure in the brain, heart and plasma of ICR mouse. ATM Inhibitor-11 exhibits anti-tumor efficacy in NCI-H441 xenograft mouse model[1].

IC50 & Target

ATM

0.32 nM (IC50)

Molecular Weight

492.59

Formula

C27H33FN6O2
CAS No.
SMILES

O=C1N(C)C2=C(N1C(C)C)C3=C(C=C(C(C4=CC=C(OCCCN5CCN(CC5)C)N=C4)=C3)F)N=C2
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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ATM Inhibitor-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATM Inhibitor-112878473-51-7ATM Inhibitor11ATM Inhibitor 11ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedMCF-7ICR mouseNCI-H441C57BL/6 mouseInhibitorinhibitorinhibit

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