2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. ATR-IN-14

ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM.

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ATR-IN-14 Chemical Structure

ATR-IN-14 Chemical Structure

CAS No. : 2765785-88-2

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ATR-IN-14 Related Antibodies

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Description

ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM[1].

IC50 & Target

ATR

 

Molecular Weight

393.42

Formula

C20H20FN7O
CAS No.
SMILES

C[C@@H]1COCCN1C2=NC3=C(N=CC(F)=C3C(C4=CC=NN4C)=C2)C5=CC=NN5
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Purity & Documentation
References
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ATR-IN-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATR-IN-142765785-88-2ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 related1,7-naphthyridineanticancer activityLoVo cellsInhibitorinhibitorinhibit

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