ATR kinase substrate peptide 

ATR kinase substrate peptide (compound 45) is a potent and selective inhibitor of ATR (Ataxia Telangiectasia and Rad3 related) protein kinase (K_i=6 nM). ATR kinase substrate peptide inhibits ATR activity by competing with ATR kinase ATP-binding sites to block ATR mediated signaling. ATR kinase substrate peptide can be used to study the role of ATR kinase in DNA damage response^[1].

1814.05

C₈₁H₁₃₂N₂₂O₂₅

Ala-Ser-Glu-Leu-Pro-Ala-Ser-Gln-Pro-Gln-Pro-Phe-Ser-Ala-Lys-Lys-Lys

ASELPASQPQPFSAKKK

O=C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Charrier J D, et al. Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents[J]. Journal of medicinal chemistry, 2011, 54(7): 2320-2330.  [Content Brief]