2. GPCR/G Protein
  3. Endothelin Receptor
  4. ATZ-1993

ATZ-1993 is an orally active, nonpeptide endothelin receptor subtype Aand endothelin receptor subtype B antagonist with pKi values of 8.69, 7.20, respectively. ATZ-1993 has the potential for the research of intimal hyperplasia after balloon denudation of the carotid artery.

For research use only. We do not sell to patients.

ATZ-1993 Chemical Structure

ATZ-1993 Chemical Structure

CAS No. : 219705-77-8

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ATZ-1993 Related Antibodies

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Description

ATZ-1993 is an orally active, nonpeptide endothelin receptor subtype Aand endothelin receptor subtype B antagonist with pKi values of 8.69, 7.20, respectively. ATZ-1993 has the potential for the research of intimal hyperplasia after balloon denudation of the carotid artery[1].

IC50 & Target[1]

ETA

8.69 (pKi)

ETB

7.20 (pKi)

In Vivo

ATZ-1993 (30 mg/kg; drinking water, daily for 1 week) inhibits the intimal hyperplasia intimal hyperplasia after balloon denudation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Japanese White male rabbits[1]
Dosage: 30 mg/kg
Administration: Drinking water, daily for 1 weeks
Result: Inhibited the intimal hyperplasia with the inhibition rate approximately 77%, increased in intima:media ratio and DNA content.
Molecular Weight

484.55

Formula

C28H28N4O4
CAS No.
SMILES

O=C(C1=NN(C(C2=CC=CC(OCC)=C2)CC)C3=C1CCC4=CC(OCC5=CN=CN=C5)=CC=C43)O
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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ATZ-1993 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATZ-1993219705-77-8ATZ1993ATZ 1993Endothelin Receptorcarotid artery balloon denudationorally activeintimal hyperplasiaInhibitorinhibitorinhibit

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HY-122237
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