2. PROTAC Cell Cycle/DNA Damage Epigenetics
  3. Ligands for Target Protein for PROTAC Aurora Kinase
  4. Aurora-A ligand 1

Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (Kd) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 (HY-168439). HLB-0532259 shows anti-tumor activity against neuroblastoma.

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Aurora-A ligand 1 Chemical Structure

Aurora-A ligand 1 Chemical Structure

CAS No. : 2541626-73-5

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Aurora-A ligand 1 Related Antibodies

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Description

Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (Kd) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 (HY-168439). HLB-0532259 shows anti-tumor activity against neuroblastoma[1].

Molecular Weight

393.44

Formula

C21H23N5O3
CAS No.
SMILES

O=C(N(C)C)C(N1C2CCCC2)=CC3=C1N=C(NC4=CC=C(C(O)=O)C=C4)N=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Aurora-A ligand 1 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aurora-A ligand 12541626-73-5Ligands for Target Protein for PROTACAurora KinaseTarget Protein-binding MoietyAntitumorNeuroblastomaXenograftSK-N-BENB cellMR-32 cell.Inhibitorinhibitorinhibit

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