2. Cell Cycle/DNA Damage Epigenetics
  3. Aurora Kinase
  4. Aurora Kinases-IN-2

Aurora Kinases-IN-2 (compound 12Aj) is a potent Aurora kinases inhibitor with IC50 values of 90 and 152 nM for Aurora A and Aurora B. Aurora Kinases-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora Kinases-IN-2 can be used for cancer research.

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Aurora Kinases-IN-2 Chemical Structure

Aurora Kinases-IN-2 Chemical Structure

CAS No. : 2241914-86-1

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Aurora Kinases-IN-2 Related Antibodies

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Aurora Kinase Aurora A Aurora B Aurora C

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Description

Aurora Kinases-IN-2 (compound 12Aj) is a potent Aurora kinases inhibitor with IC50 values of 90 and 152 nM for Aurora A and Aurora B. Aurora Kinases-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora Kinases-IN-2 can be used for cancer research[1].

IC50 & Target[1]

Aurora A

90 nM (IC50)

Aurora B

152 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
1.34 μM
Compound: 12Aj
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 32035750]
HepG2 IC50
7.3 μM
Compound: 12Aj
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 32035750]
LoVo IC50
1.64 μM
Compound: 12Aj
Antiproliferative activity against human LoVo cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human LoVo cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 32035750]
U-87MG ATCC IC50
11.5 μM
Compound: 12Aj
Antiproliferative activity against human U87 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human U87 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 32035750]
In Vitro

Aurora Kinases-IN-2 (compound 12Aj) (72 hours) has antiproliferative activity with IC50 values of 11.5 μM, 1.34 μM, 7.30 μM and 1.64 μM for U87, HeLa, HepG2 and LoVo tumor cell lines, respectively[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) inhibits Aurora A and Aurora B in HeLa cells[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours; HeLa cells) results in G2/M accumulation by regulating the expression of Cyclin B1 and cdc2[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) blocks phosphorylation of Aurora kinases in HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aurora Kinases-IN-2 Related Antibodies

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 0, 1, 5 and 10 μM
Incubation Time: 24 hours
Result: Decreased the expression level of Aurora A and B, as well as reduced phosphorylation of Aurora A on Thr288 (p-Thr288) and Aurora B on Thr232 (p-Thr232) in a dose-dependent manner.
Molecular Weight

435.86

Formula

C22H18ClN5O3
CAS No.
SMILES

O=C(NC1=CC=CC(Cl)=C1)C2=CC=C(OC3=NC(C4=C(C)ON=C4C)=CN=C3N)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Aurora Kinases-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aurora Kinases-IN-22241914-86-1Aurora Kinaseanti-tumoraurora kinasepyrazinescell cycleInhibitorinhibitorinhibit

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