2. Autophagy Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Autophagy HSP
  4. Autophagy activator-1

Autophagy activator-1 (Compound B2) is an autophagy activator Autophagy. Activator-1 ultimately leads to the activation of autophagy by downregulating key members of the HSP70 family and activating the unfolded protein response.

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Autophagy activator-1 Chemical Structure

Autophagy activator-1 Chemical Structure

CAS No. : 99174-40-0

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Autophagy activator-1 Related Antibodies

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Description

Autophagy activator-1 (Compound B2) is an autophagy activator Autophagy. Activator-1 ultimately leads to the activation of autophagy by downregulating key members of the HSP70 family and activating the unfolded protein response[1].

In Vitro

Autophagy activator-1 (Compound B2) (0.5-10 μM; 1-8 h) activates autophagy in MCF-7 and HEK-293 cells in a concentration- and time-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Autophagy activator-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: MCF-7; HEK-293
Concentration: 1, 2, 4, 6, 8 h
Incubation Time: 0.5, 1, 2, 5, 10 μM
Result: Increased the LC3-II protein level and decreased the p62 protein level.

Western Blot Analysis[1]

Cell Line: MCF-7
Concentration: 4 h
Incubation Time: 20 μM
Result: Increased the LC3-II/LC3-I ratio while simultaneously decreasing the p62/GAPDH ratio.
Molecular Weight

460.52

Formula

C25H32O8
CAS No.
SMILES

CC1=C(C(C(C(C)C)=O)=C(C(CC2=C(C(C(C(C)C)=O)=C(C(C)=C2OC)O)O)=C1OC)O)O
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Purity & Documentation
References
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Autophagy activator-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Autophagy activator-199174-40-0Autophagy activator1Autophagy activator 1AutophagyHSPHeat shock proteinsMCF-7HEK-293Inhibitorinhibitorinhibit

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