Autophagy-IN-C1

Cat. No.: HY-141813: FAQs
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Autophagy-IN-C1 not only induces apoptosis but also blocks autophagy in hepatocellular carcinoma (HCC) cells.

For research use only. We do not sell to patients.

Autophagy-IN-C1 Chemical Structure

CAS No. : 1494665-31-4

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Description

Autophagy-IN-C1 not only induces apoptosis but also blocks autophagy in hepatocellular carcinoma (HCC) cells.

Cellular Effect

Cell Line	Type	Value	Description	References
HCA1	IC₅₀	0.23 μM Compound: C1	Cytotoxicity against mouse HCA1 cells assessed as cell viability by MTT assay Cytotoxicity against mouse HCA1 cells assessed as cell viability by MTT assay	[PMID: 34558909]
Hep 3B2	IC₅₀	0.27 μM Compound: C1	Cytotoxicity against human Hep3B cells assessed as cell viability by MTT assay Cytotoxicity against human Hep3B cells assessed as cell viability by MTT assay	[PMID: 34558909]
HepG2	IC₅₀	0.69 μM Compound: C1	Cytotoxicity against human HepG2 cells assessed as cell viability by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability by MTT assay	[PMID: 34558909]
Mahlavu	IC₅₀	0.13 μM Compound: C1	Cytotoxicity against human Mahlavu cells assessed as cell viability by MTT assay Cytotoxicity against human Mahlavu cells assessed as cell viability by MTT assay	[PMID: 34558909]

Molecular Weight

578.55

Formula

C₂₉H₂₈F₆N₄O₂

CAS No.

1494665-31-4

SMILES

O=C(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)N[C@H]([C@@]2([H])[N@](CC3C=C)CC[C@H]3C2)C4=C(C=C(OC)C=C5)C5=NC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jin PR, et al. Cinchona Alkaloid-Inspired Urea-Containing Autophagy Inhibitor Shows Single-Agent Anticancer Efficacy. J Med Chem. 2021 Oct 14;64(19):14513-14525. [Content Brief]

Autophagy-IN-C1 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Autophagy-IN-C11494665-31-4AutophagyInhibitorinhibitorinhibit

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