2. Autophagy MAPK/ERK Pathway Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Autophagy JNK Reactive Oxygen Species
  4. Autophagy inducer 5

Autophagy inducer 5 (compound 21o) is a potent MCF-7 inhibitor (IC50: 2 μM), and a potential breast cancer inhibitor. Autophagy inducer 5 induces cellular autophagy by activating the ROS/JNK signaling pathway, which increases ROS generation and JNK phosphorylation, exerting cytotoxic effects.

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Autophagy inducer 5 Chemical Structure

Autophagy inducer 5 Chemical Structure

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Autophagy inducer 5 Related Antibodies

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Description

Autophagy inducer 5 (compound 21o) is a potent MCF-7 inhibitor (IC50: 2 μM), and a potential breast cancer inhibitor. Autophagy inducer 5 induces cellular autophagy by activating the ROS/JNK signaling pathway, which increases ROS generation and JNK phosphorylation, exerting cytotoxic effects[1].

Molecular Weight

648.88

Formula

C41H52N4O3
SMILES

O=C([C@]1(C)CC[C@]2(C)CC[C@]3(C)[C@]4(C)C=CC5=C(C)C6=NC7=CC=C(C(NCCN(C)C)=O)C=C7N=C6C=C5C4=CC[C@@]3(C)[C@]2([H])C1)OC
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Room temperature in continental US; may vary elsewhere.
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Autophagy inducer 5 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Autophagy inducer 5Autophagy inducer5Autophagy inducer-5AutophagyJNKReactive Oxygen Speciesc-Jun N-terminal kinaseInhibitorinhibitorinhibit

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