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  4. AV023

AV023 is a potent inhibitor of ANKRD22. AV023 promotes the expansion of gastrointestinal mucosal epithelial stem cells and indirectly activates the Wnt classical pathway, which helps the recovery of damaged gastrointestinal mucosal tissues in the body (extracted from patent CN111205231B).

For research use only. We do not sell to patients.

AV023 Chemical Structure

AV023 Chemical Structure

CAS No. : 1107710-62-2

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5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 950 In-stock
50 mg USD 1450 In-stock
100 mg USD 2250 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

AV023 is a potent inhibitor of ANKRD22. AV023 promotes the expansion of gastrointestinal mucosal epithelial stem cells and indirectly activates the Wnt classical pathway, which helps the recovery of damaged gastrointestinal mucosal tissues in the body (extracted from patent CN111205231B)[1].

Molecular Weight

414.50

Formula

C22H30N4O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N=C(C2=CC=C(OCCOCC)C=C2)NN=C1CCC(NC3CCCCC3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (60.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4125 mL 12.0627 mL 24.1255 mL
5 mM 0.4825 mL 2.4125 mL 4.8251 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4125 mL 12.0627 mL 24.1255 mL 60.3136 mL
5 mM 0.4825 mL 2.4125 mL 4.8251 mL 12.0627 mL
10 mM 0.2413 mL 1.2063 mL 2.4125 mL 6.0314 mL
15 mM 0.1608 mL 0.8042 mL 1.6084 mL 4.0209 mL
20 mM 0.1206 mL 0.6031 mL 1.2063 mL 3.0157 mL
25 mM 0.0965 mL 0.4825 mL 0.9650 mL 2.4125 mL
30 mM 0.0804 mL 0.4021 mL 0.8042 mL 2.0105 mL
40 mM 0.0603 mL 0.3016 mL 0.6031 mL 1.5078 mL
50 mM 0.0483 mL 0.2413 mL 0.4825 mL 1.2063 mL
60 mM 0.0402 mL 0.2010 mL 0.4021 mL 1.0052 mL
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AV023 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AV0231107710-62-2AV 023AV-023Othersgastrointestinal mucosalstem cellWntInhibitorinhibitorinhibit

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