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  6. Osteogenesis Compound Library
Osteogenesis Compound Library

Cat. No.: HY-L131

Ossification is a tightly regulated process, performed by specialized cells called osteoblasts. Dysregulation of this process may cause inadequate or excessive mineralization of bones or ectopic calcification, all of which have grave consequences for human health.

Osteoblasts play important roles in the process of osteogenesis and prevention of osteonecrosis. Osteoblast formation and bone formation are regulated by hormones, growth factors, cytokines, etc.

MCE offers a unique collection of 492 bone formation compounds with identified and potential inducing osteogenesis activity. MCE bone formation compound library is a useful tool for the study of bone disease drugs and pharmacology.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Description & Advantages

•    A unique collection of 492 bone formation compounds for high throughput screening (HTS) and high content screening (HCS).

•    A useful tool for the study of bone disease drugs and pharmacology.

•    Target diverse, medicinally active and cell permeable.

•    Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•    More detailed compound information with structure, IC50, and other chemical & biological data.

•    High purity and quality validated by NMR and LC/MS.

Product Details

Formulation:

A collection of 492 involved in bone formation compounds supplied as pre-dissolved Solutions or Solid
Solution: 478 compounds supplied in 10 mM solution, 13 compounds supplied in 2 mM solution, 1 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

-80°C

Composition

HDAC (126)

PPAR (52)

Wnt (28)

ERK (27)

Akt (19)

JNK (10)

COX (8)

PARP (6)

HIV (5)

JAK (5)

PI3K (5)

GLUT (4)

mTOR (4)

Src (4)

STAT (4)

AMPK (3)

CaSR (3)

CDK (3)

EGFR (3)

AAK1 (2)

CaMK (2)

FGFR (2)

MEK (2)

MMP (2)

Ras (2)

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  •  Specific Compounds
  •  Quantities
  •  Plate Map
  •  Concentration
  •  Form (Solid or Solution)
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    Product Name:
    Osteogenesis Compound Library
    Cat. No.:
    HY-L131
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack

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