2. Anti-infection Cell Cycle/DNA Damage
  3. Influenza Virus Endonuclease
  4. AV5116

AV5116 is a cap-dependent endonuclease inhibitor (CENI) that binds to the active site of the cap-dependent endonuclease (CEN) located in the N-terminal domain of the polymerase acidic. AV5116 exhibits potent inhibitory activity against influenza viruses (influenza A, B, and C viruses). AV5116 can be used for the study of influenza virus infections.

For research use only. We do not sell to patients.

AV5116

AV5116 Chemical Structure

CAS No. : 2417851-90-0

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Based on 1 publication(s) in Google Scholar

AV5116 Related Antibodies

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Description

AV5116 is a cap-dependent endonuclease inhibitor (CENI) that binds to the active site of the cap-dependent endonuclease (CEN) located in the N-terminal domain of the polymerase acidic. AV5116 exhibits potent inhibitory activity against influenza viruses (influenza A, B, and C viruses). AV5116 can be used for the study of influenza virus infections[1].

Molecular Weight

489.51

Formula

C22H17F2N3O4S2
CAS No.
SMILES

O=C1C(N(C=C2)N([C@]3([H])C4=C(SCC5=C(F)C(F)=CC=C53)C=CS4)[C@@]6([H])N1CCOC6)=C(O)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (51.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0429 mL 10.2143 mL 20.4286 mL
5 mM 0.4086 mL 2.0429 mL 4.0857 mL
View the Complete Stock Solution Preparation Table

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0429 mL 10.2143 mL 20.4286 mL 51.0715 mL
5 mM 0.4086 mL 2.0429 mL 4.0857 mL 10.2143 mL
10 mM 0.2043 mL 1.0214 mL 2.0429 mL 5.1071 mL
15 mM 0.1362 mL 0.6810 mL 1.3619 mL 3.4048 mL
20 mM 0.1021 mL 0.5107 mL 1.0214 mL 2.5536 mL
25 mM 0.0817 mL 0.4086 mL 0.8171 mL 2.0429 mL
30 mM 0.0681 mL 0.3405 mL 0.6810 mL 1.7024 mL
40 mM 0.0511 mL 0.2554 mL 0.5107 mL 1.2768 mL
50 mM 0.0409 mL 0.2043 mL 0.4086 mL 1.0214 mL
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AV5116 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AV51162417851-90-0AV 5116AV-5116Influenza VirusEndonucleasepolymerase acidicinfluenza viruscap-dependent endonucleaseInhibitorinhibitorinhibit

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