2. Metabolic Enzyme/Protease Apoptosis PROTAC NF-κB
  3. E1/E2/E3 Enzyme Apoptosis Molecular Glues NF-κB
  4. Avadomide hydrochloride

Avadomide hydrochloride  (Synonyms: CC 122 hydrochloride)

Cat. No.: HY-100507A
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Avadomide hydrochloride (CC 122 hydrochloride) is the hydrochloride form of Avadomide (HY-100507). Avadomide hydrochloride is an orally active cereblon modulator. Avadomide hydrochloride modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide hydrochloride exhibits potent antitumor and immunomodulatory activities.

For research use only. We do not sell to patients.

Avadomide hydrochloride Chemical Structure

Avadomide hydrochloride Chemical Structure

CAS No. : 1398053-45-6

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Avadomide hydrochloride Related Antibodies

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Description

Avadomide hydrochloride (CC 122 hydrochloride) is the hydrochloride form of Avadomide (HY-100507). Avadomide hydrochloride is an orally active cereblon modulator. Avadomide hydrochloride modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide hydrochloride exhibits potent antitumor and immunomodulatory activities[1][2][3].

Molecular Weight

322.75

Formula

C14H15ClN4O3
CAS No.
SMILES

O=C(N1)C(CCC1=O)N2C(C)=NC3=C(C2=O)C(N)=CC=C3.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Avadomide hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avadomide1398053-45-6CC 122CC122CC-122E1/E2/E3 EnzymeApoptosisMolecular GluesNF-κBE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseNuclear factor-κBNuclear factor-kappaBorallycereblonE3ligaseantitumorimmunomodulatorydiffuselargeB-celllymphomaDLBCLInhibitorinhibitorinhibit

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