2. Metabolic Enzyme/Protease Apoptosis PROTAC NF-κB
  3. E1/E2/E3 Enzyme Apoptosis Molecular Glues NF-κB
  4. Avadomide (Standard)

Avadomide (Standard)  (Synonyms: CC 122 (Standard))

Cat. No.: HY-100507R Purity: ≥98%
Handling Instructions Technical Support

Avadomide (Standard) is the analytical standard of Avadomide. This product is intended for research and analytical applications. Avadomide is an orally active cereblon modulator. Avadomide modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide exhibits potent antitumor and immunomodulatory activities[1][2][3].

For research use only. We do not sell to patients.

Avadomide (Standard) Chemical Structure

Avadomide (Standard) Chemical Structure

CAS No. : 1015474-32-4

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Description
Molecular Weight

286.29

Formula

C14H14N4O3
CAS No.
SMILES

O=C(C(N1C(C)=NC2=C(C(N)=CC=C2)C1=O)CC3)NC3=O
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Avadomide (Standard) Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avadomide (Standard)1015474-32-4CC 122 (Standard)E1/E2/E3 EnzymeApoptosisMolecular GluesNF-κBE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseNuclear factor-κBNuclear factor-kappaBorallycereblonE3ligaseantitumorimmunomodulatorydiffuselargeB-celllymphomaDLBCLInhibitorinhibitorinhibit

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