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Avarone ((+)-Avarone) is a sesquiterpenoidal quinone that can be isolated from Dysidea avara. Avarone shows cytotoxicity. Avarone shows antileukemic activity.

For research use only. We do not sell to patients.

Avarone Chemical Structure

Avarone Chemical Structure

CAS No. : 55303-99-6

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Description

Avarone ((+)-Avarone) is a sesquiterpenoidal quinone that can be isolated from Dysidea avara. Avarone shows cytotoxicity. Avarone shows antileukemic activity[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
30.03 μM
Compound: 1
Cytotoxicity against human A549 cells assessed as cell survival after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell survival after 72 hrs by MTT assay
[PMID: 26476666]
HaCaT IC50
37 μM
Compound: 2
Cytotoxicity against human HaCaT cells after 72 hrs by MTT assay
Cytotoxicity against human HaCaT cells after 72 hrs by MTT assay
[PMID: 27128177]
HeLa IC50
18.12 μM
Compound: 1
Cytotoxicity against human HeLa cells assessed as cell survival after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as cell survival after 72 hrs by MTT assay
[PMID: 26476666]
HeLa IC50
26.8 μM
Compound: 2
Cytotoxicity against human HeLa cells assessed as decrease in total cellular protein by kenacid blue R binding method
Cytotoxicity against human HeLa cells assessed as decrease in total cellular protein by kenacid blue R binding method
[PMID: 19995673]
K562 IC50
17.08 μM
Compound: 1
Cytotoxicity against human K562 cells assessed as cell survival after 72 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as cell survival after 72 hrs by MTT assay
[PMID: 26476666]
K562 IC50
4.9 μM
Compound: 2
Cytotoxicity against human K562 cells by MTT assay
Cytotoxicity against human K562 cells by MTT assay
[PMID: 19995673]
MDA-MB-453 IC50
16.71 μM
Compound: 1
Cytotoxicity against human MDA-MB-453 cells assessed as cell survival after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-453 cells assessed as cell survival after 72 hrs by MTT assay
[PMID: 26476666]
MRC5 IC50
> 200 μM
Compound: 1
Cytotoxicity against human MRC5 cells assessed as cell survival after 72 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as cell survival after 72 hrs by MTT assay
[PMID: 26476666]
NCI-H460 IC50
24 μM
Compound: 2
Cytotoxicity against multidrug resistant human NCI-H460 cells after 72 hrs by MTT assay
Cytotoxicity against multidrug resistant human NCI-H460 cells after 72 hrs by MTT assay
[PMID: 27128177]
NCI-H460 IC50
84 μM
Compound: 2
Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay
[PMID: 27128177]
PBMC IC50
4.5 μM
Compound: 2
Cytotoxicity against human phytohemagglutininin-stimulated PBMC cells assessed as growth inhibition by MTT assay
Cytotoxicity against human phytohemagglutininin-stimulated PBMC cells assessed as growth inhibition by MTT assay
[PMID: 19995673]
PBMC IC50
4.8 μM
Compound: 2
Cytotoxicity against human PBMC cells by MTT assay
Cytotoxicity against human PBMC cells by MTT assay
[PMID: 19995673]
In Vitro

Avarone (24, 48, 72 h) inhibits U937 cell growth with IC50s of 95.8, 52.9, 33.5 µM at 24, 48, 72 h, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[2]

Cell Line: L5178Y, Melanoma, Hela, fibroblasts, human gingival cells
Concentration:
Incubation Time:
Result: Showed cytotoxicity for L5178Y, Melanoma, Hela, fibroblasts, human gingival cells with ED50s of 0.62, 26.4, 8.7, 11.3, 76.4 µM, respectively.
In Vivo

Avarone (10 mg/kg; i.p.; once daily for 5 days) shows increases life span of leukemic mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-9 months, 32-35 g Male outbred NMIR mice (L5178Y cells)[2]
Dosage: 10 mg/kg
Administration: I.p.; once daily for 5 days
Result: Increased life span over controls by 146% when treatment was begun 1 day after tumor implantation and by 87% when treatment was delayed until day 8.
Molecular Weight

312.45

Formula

C21H28O2

CAS No.
SMILES

O=C1C(C[C@]2(C)[C@@H](C)CC[C@]3(C)C(C)=CCC[C@@]23[H])=CC(C=C1)=O

Structure Classification
Initial Source

Dysidea avara

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
Avarone
Cat. No.:
HY-135771
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