2. Natural Products
  3. Marine natural products Others
  4. Avarone

Avarone ((+)-Avarone) is a sesquiterpenoidal quinone that can be isolated from Dysidea avara. Avarone shows cytotoxicity. Avarone shows antileukemic activity.

For research use only. We do not sell to patients.

Avarone Chemical Structure

Avarone Chemical Structure

CAS No. : 55303-99-6

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Avarone Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Avarone ((+)-Avarone) is a sesquiterpenoidal quinone that can be isolated from Dysidea avara. Avarone shows cytotoxicity. Avarone shows antileukemic activity[1][2].

In Vitro

Avarone (24, 48, 72 h) inhibits U937 cell growth with IC50s of 95.8, 52.9, 33.5 µM at 24, 48, 72 h, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Avarone Related Antibodies

Cell Cytotoxicity Assay[2]

Cell Line: L5178Y, Melanoma, Hela, fibroblasts, human gingival cells
Concentration:
Incubation Time:
Result: Showed cytotoxicity for L5178Y, Melanoma, Hela, fibroblasts, human gingival cells with ED50s of 0.62, 26.4, 8.7, 11.3, 76.4 µM, respectively.
In Vivo

Avarone (10 mg/kg; i.p.; once daily for 5 days) shows increases life span of leukemic mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-9 months, 32-35 g Male outbred NMIR mice (L5178Y cells)[2]
Dosage: 10 mg/kg
Administration: I.p.; once daily for 5 days
Result: Increased life span over controls by 146% when treatment was begun 1 day after tumor implantation and by 87% when treatment was delayed until day 8.
Molecular Weight

312.45

Formula

C21H28O2
CAS No.
SMILES

O=C1C(C[C@]2(C)[C@@H](C)CC[C@]3(C)C(C)=CCC[C@@]23[H])=CC(C=C1)=O
Structure Classification
Initial Source

Dysidea avara
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Avarone Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avarone55303-99-6(+)-AvaroneOtherscytotoxicityantileukemic activityU937 cellsL5178Y cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Avarone
Cat. No.:
HY-135771
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.