Avenanthramide-C methyl ester 

Avenanthramide-C methyl ester is an anti-inflammatory agent and NF-κB inhibitor that inhibits the secretion of pro-inflammatory factors. Avenanthramide-C methyl ester inhibits NF-κB activation by inhibiting IKK and IκB phosphorylation and inhibiting proteasome activity^[1].

Avenanthramide-C methyl ester dose-dependently reduces mRNA expression and secretion of IL-6, IL-8, and MCP-1^[1].
Inhibits IL-1β and TNFα-stimulated NF-κB activation^[1].
Inhibits NFκB-dependent reporter gene expression activated by TNFR-associated factors 2 and 6 (TRAF2, TRAF6) and NFκB-inducing kinase (NIK)^[1].
Avenanthramide-C methyl ester also dose-dependently reduces the phosphorylation levels of IκB kinase (IKK) and IκB and prevents IκB degradation as measured by Western blotting^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

329.30

C₁₇H₁₅NO₆

955382-52-2

COC(C1=C(C=CC(O)=C1)NC(/C=C/C2=CC(O)=C(C=C2)O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Guo W, et al. Avenanthramides, polyphenols from oats, inhibit IL-1beta-induced NF-kappaB activation in endothelial cells. Free Radic Biol Med. 2008 Feb 1;44(3):415-29.  [Content Brief]