2. NF-κB
  3. NF-κB
  4. Avenanthramide-C methyl ester

Avenanthramide-C methyl ester is an anti-inflammatory agent and NF-κB inhibitor that inhibits the secretion of pro-inflammatory factors. Avenanthramide-C methyl ester inhibits NF-κB activation by inhibiting IKK and IκB phosphorylation and inhibiting proteasome activity.

For research use only. We do not sell to patients.

Avenanthramide-C methyl ester Chemical Structure

Avenanthramide-C methyl ester Chemical Structure

CAS No. : 955382-52-2

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Avenanthramide-C methyl ester Related Antibodies

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Description

Avenanthramide-C methyl ester is an anti-inflammatory agent and NF-κB inhibitor that inhibits the secretion of pro-inflammatory factors. Avenanthramide-C methyl ester inhibits NF-κB activation by inhibiting IKK and IκB phosphorylation and inhibiting proteasome activity[1].

In Vitro

Avenanthramide-C methyl ester dose-dependently reduces mRNA expression and secretion of IL-6, IL-8, and MCP-1[1].
Inhibits IL-1β and TNFα-stimulated NF-κB activation[1].
Inhibits NFκB-dependent reporter gene expression activated by TNFR-associated factors 2 and 6 (TRAF2, TRAF6) and NFκB-inducing kinase (NIK)[1].
Avenanthramide-C methyl ester also dose-dependently reduces the phosphorylation levels of IκB kinase (IKK) and IκB and prevents IκB degradation as measured by Western blotting[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Avenanthramide-C methyl ester Related Antibodies

Western Blot Analysis[1]

Cell Line: WB HAEC and HUVEC cells
Concentration: 1, 10, 40, and 100 μM
Incubation Time: 24 h
Result: Inhibited NF-κB p50 and p65 DNA binding activity of nuclear.
Suppresseed IL-1β-stimulated secretion of IL-6, IL-8, and MCP-1 by HAEC in a concentration-dependent manner.
Inhibited the phosphorylation of IKKα/IKKβ and IκB and degradation of IκB induced by IL-1β.

RT-PCR[1]

Cell Line: WB HAEC and HUVEC cells
Concentration: 40, and 100 μM
Incubation Time: 24 h
Result: Suppressed IL-1β-stimulated mRNA expression of IL-6, IL-8, and MCP-1 by HAEC in a concentration-dependent manner.
Molecular Weight

329.30

Formula

C17H15NO6
CAS No.
SMILES

COC(C1=C(C=CC(O)=C1)NC(/C=C/C2=CC(O)=C(C=C2)O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Avenanthramide-C methyl ester Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avenanthramide-C methyl ester955382-52-2NF-κBNuclear factor-κBNuclear factor-kappaBAtherosclerosisEndothelial cellCytokinesHAECHUVECInhibitorinhibitorinhibit

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