AZ'3137

Cat. No.: HY-162702: FAQs
Data Sheet Handling Instructions Technical Support

AZ‘3137 (Compound 22) is an orally active PROTAC-type androgen receptor (AR) degrader, with a DC₅₀ value of 22 nM. AZ'3137 can inhibit cell proliferation of LNCaP, with a GI₅₀ value of 74 nM. AZ'3137 can inhibit AR signaling and tumor growth in prostate cancer mice (Red: AR antagonists; Blue: CRBN ligand (HY-A0003); Black: linker).

For research use only. We do not sell to patients.

AZ'3137 Chemical Structure

CAS No. : 2960179-55-7

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

AZ'3137 (Compound 22) can inhibit AR signaling and cell proliferation of prostate cancer cell line LNCaP^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1].

Cell Line:	LNCaP cells
Concentration:	0-10 μM
Incubation Time:	7 days
Result:	Inhibited the proliferation of LNCaPs with a GI₅₀ value of 74 nM.

In Vivo

AZ'3137 (Compound 22) inhibits tumor growth in prostate cancer mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Immunocompromised NOD SCID male mice implanted with C4-2 cell subcutaneous tumors^[1].
Dosage:	30 mg/kg
Administration:	Oral gavage (p.o.); once daily
Result:	Degraded AR and inhibited tumor growth.

Molecular Weight

801.87

Formula

C₄₃H₄₇F₄N₇O₄

CAS No.

2960179-55-7

SMILES

COC1=CC(N2CCN(CC3CCN(C4=CC=C(C5CCN(C6=CC=C(C#N)C(C(F)(F)F)=C6F)CC5)C=C4)CC3)CC2)=CC7=C1C(N(C8CCC(NC8=O)=O)C7)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bagal SK, et al. Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer. J Med Chem. 2024 Jul 25;67(14):11732-11750. [Content Brief]

AZ'3137 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ'31372960179-55-7Androgen ReceptorPROTACsandrogenprostatic cancerorally activeInhibitorinhibitorinhibit

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