2. Vitamin D Related/Nuclear Receptor PROTAC
  3. Androgen Receptor PROTACs
  4. AZ'3137

AZ‘3137 (Compound 22) is an orally active PROTAC-type androgen receptor (AR) degrader, with a DC50 value of 22 nM. AZ'3137 can inhibit cell proliferation of LNCaP, with a GI50 value of 74 nM. AZ'3137 can inhibit AR signaling and tumor growth in prostate cancer mice (Red: AR antagonists; Blue: CRBN ligand (HY-A0003); Black: linker).

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AZ'3137 Chemical Structure

AZ'3137 Chemical Structure

CAS No. : 2960179-55-7

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AZ'3137 Related Antibodies

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Description

AZ‘3137 (Compound 22) is an orally active PROTAC-type androgen receptor (AR) degrader, with a DC50 value of 22 nM. AZ'3137 can inhibit cell proliferation of LNCaP, with a GI50 value of 74 nM. AZ'3137 can inhibit AR signaling and tumor growth in prostate cancer mice (Red: AR antagonists; Blue: CRBN ligand (HY-A0003); Black: linker)[1].
In Vitro

AZ'3137 (Compound 22) can inhibit AR signaling and cell proliferation of prostate cancer cell line LNCaP[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AZ'3137 Related Antibodies

Cell Proliferation Assay[1].

Cell Line: LNCaP cells
Concentration: 0-10 μM
Incubation Time: 7 days
Result: Inhibited the proliferation of LNCaPs with a GI50 value of 74 nM.
In Vivo

AZ'3137 (Compound 22) inhibits tumor growth in prostate cancer mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Immunocompromised NOD SCID male mice implanted with C4-2 cell subcutaneous tumors[1].
Dosage: 30 mg/kg
Administration: Oral gavage (p.o.); once daily
Result: Degraded AR and inhibited tumor growth.
Molecular Weight

801.87

Formula

C43H47F4N7O4
CAS No.
SMILES

COC1=CC(N2CCN(CC3CCN(C4=CC=C(C5CCN(C6=CC=C(C#N)C(C(F)(F)F)=C6F)CC5)C=C4)CC3)CC2)=CC7=C1C(N(C8CCC(NC8=O)=O)C7)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AZ'3137 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ'31372960179-55-7Androgen ReceptorPROTACsandrogenprostatic cancerorally activeInhibitorinhibitorinhibit

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