2. Anti-infection
  3. Virus Protease Influenza Virus
  4. Azaribine

Azaribine  (Synonyms: 2',3',5'-Tri-O-acetyl-6-azauridine)

Cat. No.: HY-B1537 Purity: ≥99.0%
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Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity (EC50=3.80 nM-1.73 μM against influenza A and B viruses; EC50=1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research.

For research use only. We do not sell to patients.

Azaribine Chemical Structure

Azaribine Chemical Structure

CAS No. : 2169-64-4

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Based on 1 publication(s) in Google Scholar

Azaribine Related Antibodies

Top Publications Citing Use of Products

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Description

Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity (EC50=3.80 nM-1.73 μM against influenza A and B viruses; EC50=1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research[1][2].

In Vitro

Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine; 0-2 μM; 48 h) has cytotoxicity on MDCK cells (MTT: CC50=19.66 μM)[1].
Azaribine shows a potent inhibitory effect on BIRFLU multiplication (MDCK cells: EC50=0.29 μM; A549 cells: EC50=0.55 μM)[1].
Azaribine shows against seasonal H1N1 and H3N2 IAVs and IBV during posttreatment in MDCK cells with EC50 of 0.60 μM, 0.77 μM, 0.80 μM[1].
Azaribine is against NC H1N1 during posttreatment in 16HBE cells (EC50=1.58 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azaribine Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: MDCK cells
Concentration: 0-2 μM
Incubation Time: 48 h
Result: Had cytotoxicity on MDCK cells (CC50=19.66 μM).
Molecular Weight

371.30

Formula

C14H17N3O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(OC[C@@H]1[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](N2N=CC(NC2=O)=O)O1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 3.8 mg/mL (10.23 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6932 mL 13.4662 mL 26.9324 mL
5 mM 0.5386 mL 2.6932 mL 5.3865 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6932 mL 13.4662 mL 26.9324 mL 67.3310 mL
5 mM 0.5386 mL 2.6932 mL 5.3865 mL 13.4662 mL
10 mM 0.2693 mL 1.3466 mL 2.6932 mL 6.7331 mL
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Azaribine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azaribine2169-64-42',3',5'-Tri-O-acetyl-6-azauridineVirus ProteaseInfluenza Virusorotidine monophosphate decarboxylaseOMPDRNA virusesgenome replicationtranscriptioninfluenza AB virusesZIKV ParaibaAzauridinepsoriasisInhibitorinhibitorinhibit

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