AZD 2066 hydrate

Cat. No.: HY-110255A: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 hydrate has antinociception effects.

For research use only. We do not sell to patients.

AZD 2066 hydrate Chemical Structure

Size	Price	Stock
5 mg	USD 585	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of AZD 2066 hydrate:

AZD 2066 Get quote

1 Publications Citing Use of MCE AZD 2066 hydrate

•ACS Chem Neurosci. 2019 Nov 20;10(11):4558-4570. [Abstract]

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All mGluR Isoform Specific Products:

View All Isoforms

mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

Biological Activity
Purity & Documentation
References
Customer Review

Description

AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 hydrate has antinociception effects^[1].

IC₅₀ & Target^[1]

mGluR5

In Vitro

AZD 2066 (1-10 μM) inhibits Ca²⁺ response, with IC₅₀s of 27.2±9.1, 3.56±0.52, 96.2±17.8, and 380±78.0 nM in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures respectively^[2].
AZD 2066 (1-10 μM) inhibits the oscillatory Ca²⁺ response which induced by bath application of DHPG, and blocks either DHPG or Quis eﬀects in mGlu5/HEK cells^[2].
AZD 2066 (1-10 μM) has less eﬀective in striatal neurons^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AZD 2066 (0.03-30 mg/kg; p.o.) shows discriminative effects in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (weighing 240-250 g)^[1]
Dosage:	0.03, 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration:	P.o. (60 minutes after administration)
Result:	Caused full and dose-dependent AZD9272-appropriate responding.

Clinical Trial

Molecular Weight

386.33

Formula

C₁₉H₁₆ClN₅O₂.1/4H₂O

Appearance

Solid

Color

Off-white to light yellow

SMILES

CN1C(C2=CC=NC=C2)=NN=C1O[C@@H](C3=NOC(C4=CC(Cl)=CC=C4)=C3)C.O.[1/4]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (248 KB)

Handling Instructions (2659 KB)

References

[1]. Swedberg MDB, et, al. AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects. J Pharmacol Exp Ther. 2014 Aug; 350(2): 212-22. [Content Brief]

[2]. Jong YJI, et, al. Location and Cell-Type-Specific Bias of Metabotropic Glutamate Receptor, mGlu 5, Negative Allosteric Modulators. ACS Chem Neurosci. 2019 Nov 20; 10(11): 4558-4570. [Content Brief]

AZD 2066 hydrate Related Classifications

Neurological Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD 2066AZD2066AZD-2066mGluRMetabotropic glutamate receptorsmGluR5antinociceptionInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks