Azido-PEG6-amine 

Azido-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. Azido-PEG6-amine is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[2]. Azido-PEG6-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

350.41

C₁₄H₃₀N₄O₆

957486-82-7

Liquid

Colorless to light yellow

NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]

Room temperature in continental US; may vary elsewhere.

• [1]. Williams EGL, et al. Glycosylated Reversible Addition-Fragmentation Chain Transfer Polymers with Varying Polyethylene Glycol Linkers Produce Different Short Interfering RNA Uptake, Gene Silencing, and Toxicity Profiles. Biomacromolecules. 2017 Dec 11;18(12):4099-4112.  [Content Brief]

  [2]. Philip Wilson Howard, et al. Pyrrolobenzodiazepines and conjugates thereof. WO2014140862A2.