Azidoacetic Acid (Synonyms: 2-Azidoacetic acid)

Cat. No.: HY-151719 Purity: 99.01%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Azidoacetic Acid (2-Azidoacetic acid) (compound 92-1) is a click chemistry reagent containing an azide group. Azidoacetic Acid can be used as a small molecule tool for the synthesis of PROTAC. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Azidoacetic Acid Chemical Structure

CAS No. : 18523-48-3

Size	Price	Stock	Quantity
100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
1 g	USD 140	In-stock	Estimated Time of Arrival: December 31
5 g	USD 269	In-stock	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

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Purity & Documentation
References
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Description

Azidoacetic Acid (2-Azidoacetic acid) (compound 92-1) is a click chemistry reagent containing an azide group. Azidoacetic Acid can be used as a small molecule tool for the synthesis of PROTAC^[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Molecular Weight

101.06

Formula

C₂H₃N₃O₂

CAS No.

18523-48-3

Appearance

Liquid (Density: 1.350 g/cm³)

Color

Colorless to light yellow

SMILES

[N-]=[N+]=NCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 175 mg/mL (1731.64 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	9.8951 mL	49.4756 mL	98.9511 mL
5 mM	1.9790 mL	9.8951 mL	19.7902 mL
10 mM	0.9895 mL	4.9476 mL	9.8951 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.01%

Select Batch:

Data Sheet (267 KB) SDS (466 KB)

COA (242 KB) HNMR (225 KB) LCMS (86 KB)

Handling Instructions (2659 KB)

References

[1]. Ma Xin et al. Class of novel Smad3 protein degraders and application. Patent WO2022148459A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	9.8951 mL	49.4756 mL	98.9511 mL	247.3778 mL
	5 mM	1.9790 mL	9.8951 mL	19.7902 mL	49.4756 mL
	10 mM	0.9895 mL	4.9476 mL	9.8951 mL	24.7378 mL
	15 mM	0.6597 mL	3.2984 mL	6.5967 mL	16.4919 mL
	20 mM	0.4948 mL	2.4738 mL	4.9476 mL	12.3689 mL
	25 mM	0.3958 mL	1.9790 mL	3.9580 mL	9.8951 mL
	30 mM	0.3298 mL	1.6492 mL	3.2984 mL	8.2459 mL
	40 mM	0.2474 mL	1.2369 mL	2.4738 mL	6.1844 mL
	50 mM	0.1979 mL	0.9895 mL	1.9790 mL	4.9476 mL
	60 mM	0.1649 mL	0.8246 mL	1.6492 mL	4.1230 mL
	80 mM	0.1237 mL	0.6184 mL	1.2369 mL	3.0922 mL
	100 mM	0.0990 mL	0.4948 mL	0.9895 mL	2.4738 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Azidoacetic Acid Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azidoacetic Acid18523-48-32-Azidoacetic acidADC LinkerAntibody-drug conjugates linkerazidePROTACsmall molecule toolInhibitorinhibitorinhibit

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