Azilsartan mepixetil-d₅  (Synonyms: QR-01019-d-d₅)

Azilsartan mepixetil-d₅ (QR-01019-d₅) is deuterium labeled Azilsartan mepixetil. Azilsartan mepixetil is the antagonist of angiotensin II receptor. Azilsartan mepixetil has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil achieves ideal protective effect for heart and kidney functions. Azilsartan mepixetil has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A)^[1][2].

683.72

C₃₆H₂₉D₅N₆O₈

1596357-16-2

O=C1NC(C2=CC=CC=C2C(C=C3)=CC=C3CN4C(OC(C([2H])([2H])[2H])([2H])[2H])=NC5=CC=CC(C(OC(OC(OCC6=NC(C)=C(C)N=C6C)=O)C)=O)=C54)=NO1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Ma, Jianyi, et al. Compound and preparation method thereof, composition and application. Patent CN107400122A.